Gene: TRIP11

Alternate names for this Gene: ACG1A|CEV14|GMAP-210|GMAP210|ODCD|TRIP-11|TRIP230

Gene Summary: This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.

Gene is located in Chromosome: 14

Location in Chromosome : 14q32.12

Description of this Gene: thyroid hormone receptor interactor 11

Type of Gene: protein-coding

rs1085307101 in TRIP11 gene and Achondrogenesis type 1A PMID 20089971 2010 Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210.

rs1133441 in TRIP11 gene and Body Height PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.

PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.

PMID 25429064 2015 Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

PMID 18391950 2008 Identification of ten loci associated with height highlights new biological pathways in human growth.

rs7155279 in TRIP11 gene and Forced expiratory volume function PMID 26635082 2015 Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

rs7155279 in TRIP11 gene and Height PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.

PMID 18391950 2008 Identification of ten loci associated with height highlights new biological pathways in human growth.

rs8007661 in TRIP11 gene and Physical Activity Measurement PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

rs149079426 in TRIP11 gene and Spondylometaphyseal dysplasia with dentinogenesis imperfecta PMID 30728324 2019 Hypomorphic mutations of TRIP11 cause odontochondrodysplasia.

rs7155279 in TRIP11 gene and Vital capacity PMID 26635082 2015 Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

rs10083447 in TRIP11 gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.