Gene: TUSC3

Alternate names for this Gene: D8S1992|M33|MRT22|MRT7|MagT2|N33|OST3A|SLC58A2

Gene Summary: This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform.

Gene is located in Chromosome: 8

Location in Chromosome : 8p22

Description of this Gene: tumor suppressor candidate 3

Type of Gene: protein-coding

rs12679528 in TUSC3 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs352759 in TUSC3 gene and Major Depressive Disorder PMID 29559929 2018 Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.

rs76830538 in TUSC3 gene and Schizophrenia PMID 27846195 2017 Genome-wide association study of paliperidone efficacy.

rs352759 in TUSC3 gene and Unipolar Depression PMID 29559929 2018 Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.

rs352759 in TUSC3 gene and response to SSRI PMID 29559929 2018 Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.