Gene: WDR5

Alternate names for this Gene: BIG-3|CFAP89|SWD3

Gene Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene is located in Chromosome: 9

Location in Chromosome : 9q34.2

Description of this Gene: WD repeat domain 5

Type of Gene: protein-coding

rs11556391 in WDR5 gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.