Gene: YAP1

Alternate names for this Gene: COB1|YAP|YAP2|YAP65|YKI

Gene Summary: This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene is located in Chromosome: 11

Location in Chromosome : 11q22.1

Description of this Gene: Yes1 associated transcriptional regulator

Type of Gene: protein-coding

rs10895278 in YAP1 gene and Birth Weight PMID 31043758 2019 Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

rs117496742 in YAP1 gene and Cleft Palate PMID 27018472 2016 A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3.

rs10895275 in YAP1 gene and Migraine Disorders PMID 27322543 2016 Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

rs11225154 in YAP1 gene and Polycystic Ovary Syndrome PMID 26416764 2015 Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome.

PMID 30566500 2018 Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.

PMID 22885925 2012 Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.

rs12787996 in YAP1 gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.