Gene: ZFPM2

Alternate names for this Gene: DIH3|FOG2|SRXY9|ZC2HC11B|ZNF89B|hFOG-2

Gene Summary: The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.

Gene is located in Chromosome: 8

Location in Chromosome : 8q23.1

Description of this Gene: zinc finger protein, FOG family member 2

Type of Gene: protein-coding

Gene: ZFPM2-AS1

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

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rs200834568 in ZFPM2;ZFPM2-AS1 gene and 46,XY SEX REVERSAL 9 PMID 24549039 2014 Mutations in the FOG2/ZFPM2 gene are associated with anomalies of human testis determination.

rs6993770 in ZFPM2;ZFPM2-AS1 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs6993770 in ZFPM2;ZFPM2-AS1 gene and Interleukin 12 Measurement PMID 27989323 2017 Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.

rs6993770 in ZFPM2;ZFPM2-AS1 gene and Platelet Component Distribution Width Measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs2343592 in ZFPM2;ZFPM2-AS1 gene and Platelet Count measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 26805783 2016 Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.

PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 22139419 2011 New gene functions in megakaryopoiesis and platelet formation.

rs6993770 in ZFPM2;ZFPM2-AS1 gene and Platelet mean volume determination (procedure) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs6993770 in ZFPM2;ZFPM2-AS1 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs6993696 in ZFPM2;ZFPM2-AS1 gene and Vascular Endothelial Growth Factor Measurement PMID 21757650 2011 Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.

PMID 26910538 2016 Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies.

rs4541868 in ZFPM2;ZFPM2-AS1 gene and Venous Thromboembolism PMID 31420334 2019 Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.

PMID 25772935 2015 Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.

PMID 28373160 2017 Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor.