PMID 25042611 2014 The genetics of hemoglobin A2 regulation in sickle cell anemia.
PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.
rs766432 in
BCL11A gene and
Fetal hemoglobin determination
PMID 17767159 2007 A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.
PMID 22936743 2012 Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.
PMID 20018918 2010 Genome-wide association studies also validated a previously identified SNP (rs766432) in BCL11A, a gene known to affect fetal hemoglobin levels (P = 2.6E-21) and in Thailand and Hong Kong subjects.
PMID 27022141 2016 Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease.
PMID 21326311 2011 Recently, BCL11A (zinc-finger protein) was identified as a regulator of HbF, and the strongest association signals were observed either directly for rs766432 or for correlated single-nucleotide polymorphisms (SNPs).
rs766432 in
BCL11A gene and
Hemoglobin A2 measurement
PMID 25042611 2014 The genetics of hemoglobin A2 regulation in sickle cell anemia.
rs766432 in
BCL11A gene and
Hemoglobin E disease
PMID 20183929 2010 A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E.
rs766432 in
BCL11A gene and
Reticulocyte count (procedure)
PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.