Condition: Folic acid measurement
rs3782886 in
BRAP gene and
Folic acid measurement
PMID 29953918 2018 Surprisingly, we discovered three novel loci rs3782886, rs671, and rs4646776 of ALDH2 gene were suggestively significantly associated with folate serum folate levels in the male population studied (P = 2.17 × 10<sup>-7</sup>, P = 3.60 × 10<sup>-7</sup>, P = 3.99 × 10<sup>-7</sup>, respectively) after adjusting for population stratification, BMI and age.
rs2639453 in
KIAA2013 gene and
Folic acid measurement
PMID 29953918 2018 Identification of three novel loci of ALDH2 Gene for Serum Folate levels in a Male Chinese Population by Genome-Wide Association Study.
rs2670029 in
LOC101929415 gene and
Folic acid measurement
PMID 29953918 2018 Identification of three novel loci of ALDH2 Gene for Serum Folate levels in a Male Chinese Population by Genome-Wide Association Study.
rs1801133 in
MTHFR gene and
Folic acid measurement
PMID 30339177 2018 The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 × 10-17), serum folate (P = 2.82 × 10-11), and plasma total homocysteine (P = 1.26 × 10-19) concentrations.
PMID 29953918 2018 We validated that rs1801133 in MTHFR was significantly involved in serum folate (P = 4.21 × 10<sup>-19</sup>).