Gene: ADGRL3

Alternate names for this Gene: CIRL3|CL3|LEC3|LPHN3

Gene Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.

Gene is located in Chromosome: 4

Location in Chromosome : 4q13.1

Description of this Gene: adhesion G protein-coupled receptor L3

Type of Gene: protein-coding

rs995447 in ADGRL3 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 23670970 2013 Genetic modifiers of cystic fibrosis-related diabetes.

rs6856328 in ADGRL3 gene and Memory, Short-Term PMID 21107309 2011 Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.