Gene: ARHGAP24
Alternate names for this Gene: FILGAP|RC-GAP72|RCGAP72|p73|p73RhoGAP
Gene Summary: This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants.
Gene is located in Chromosome: 4
Location in Chromosome : 4q21.23-q21.3
Description of this Gene: Rho GTPase activating protein 24
Type of Gene: protein-coding
rs16995986 in
ARHGAP24 gene and
Asthma
PMID 25918132 2015 Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma.
rs17010957 in
ARHGAP24 gene and
Body Height
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 28270201 2017 Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.
rs11732231 in
ARHGAP24 gene and
Electrocardiogram: P-R interval
PMID 23139255 2012 Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.
PMID 29127183 2018 Genome-wide association study of PR interval in Hispanics/Latinos identifies novel locus at ID2.
PMID 30679814 2019 Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.
PMID 30046033 2018 PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.
PMID 20062063 2010 Several common variants modulate heart rate, PR interval and QRS duration.
PMID 20062060 2010 Genome-wide association study of PR interval.
rs1026872 in
ARHGAP24 gene and
Hair Color
PMID 30531825 2018 Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.
rs111882035 in
ARHGAP24 gene and
Memory performance
PMID 29274321 2018 Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.
rs12506184 in
ARHGAP24 gene and
Systolic Pressure
PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
PMID 29455858 2018 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
PMID 27618452 2016 The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 28739976 2017 Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
PMID 27841878 2017 Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
PMID 26390057 2015 Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.