Gene: ARHGEF5

Alternate names for this Gene: GEF5|P60|TIM|TIM1

Gene Summary: Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.

Gene is located in Chromosome: 7

Location in Chromosome : 7q35

Description of this Gene: Rho guanine nucleotide exchange factor 5

Type of Gene: protein-coding

rs720475 in ARHGEF5 gene and Breast Carcinoma PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

PMID 25751625 2015 Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.

rs720475 in ARHGEF5 gene and Malignant neoplasm of breast PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.