Gene: CASC19

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: PCAT1

Alternate names for this Gene: PCA1|PCAT-1|PiHL

Gene Summary: This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This RNA negatively regulates the BRCA2 tumor suppressor protein and positively regulates Myc oncoprotein. It contains binding sites for microRNAs, and may act as a sponge for microRNAs that regulate cell growth pathways.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: prostate cancer associated transcript 1

Type of Gene: ncRNA

rs140099016 in CASC19;PCAT1 gene and Chronic Lymphocytic Leukemia PMID 26956414 2016 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.

PMID 20062064 2010 We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)).

PMID 28165464 2017 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

PMID 23770605 2013 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.

rs2445610 in CASC19;PCAT1 gene and Hypothyroidism PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1456306 in CASC19;PCAT1 gene and Malignant neoplasm of prostate PMID 22923026 2012 Evaluating genetic risk for prostate cancer among Japanese and Latinos.

PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

rs2456449 in CASC19;PCAT1 gene and Multiple Sclerosis PMID 24076602 2013 Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

rs2456449 in CASC19;PCAT1 gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

rs138042437 in CASC19;PCAT1 gene and Prostate carcinoma PMID 27262462 2016 Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21.

PMID 17401366 2007 Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

rs140099016 in CASC19;PCAT1 gene and Small Lymphocytic Lymphoma PMID 26956414 2016 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.

PMID 28165464 2017 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

rs191785584 in CASC19;PCAT1 gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.