Gene: CCDC170

Alternate names for this Gene: C6orf97|bA282P11.1

Gene Summary: The function of this gene and its encoded protein is not known. Several genome-wide association studies have implicated the region around this gene to be involved in breast cancer and bone mineral density, but no link to this specific gene has been found.

Gene is located in Chromosome: 6

Location in Chromosome : 6q25.1

Description of this Gene: coiled-coil domain containing 170

Type of Gene: protein-coding

rs141252918 in CCDC170 gene and Bipolar Disorder PMID 31164008 2019 GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.

rs11155797 in CCDC170 gene and Bone Density PMID 19801982 2009 Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.

PMID 24249740 2014 Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.

PMID 22504420 2012 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

PMID 19079262 2009 New sequence variants associated with bone mineral density.

PMID 18445777 2008 Multiple genetic loci for bone mineral density and fractures.

PMID 29304378 2018 Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

PMID 23437003 2013 Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.

rs1871859 in CCDC170 gene and Bone Mineral Density Test PMID 24249740 2014 Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.

PMID 22504420 2012 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

PMID 23437003 2013 Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.

rs12662670 in CCDC170 gene and Breast Carcinoma PMID 25751625 2015 Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.

PMID 27117709 2016 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.

PMID 27354352 2016 Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.

PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

PMID 29058716 2017 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

rs10872673 in CCDC170 gene and Cardiovascular Diseases PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1971256 in CCDC170 gene and Endometriosis PMID 28537267 2017 Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.

rs954238 in CCDC170 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs9371220 in CCDC170 gene and Low density lipoprotein cholesterol measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

rs141252918 in CCDC170 gene and Major Depressive Disorder PMID 31164008 2019 GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.

PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs3757318 in CCDC170 gene and Malignant neoplasm of breast PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

PMID 23535733 2013 Genome-wide association studies identify four ER negative-specific breast cancer risk loci.

rs141252918 in CCDC170 gene and Schizophrenia PMID 31164008 2019 GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.

rs4870044 in CCDC170 gene and Serum total cholesterol measurement PMID 29083408 2017 Exome-wide association study of plasma lipids in >300,000 individuals.

PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

rs141252918 in CCDC170 gene and Suicide attempt PMID 31164008 2019 GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.