Gene: CD86

Alternate names for this Gene: B7-2|B7.2|B70|CD28LG2|LAB72

Gene Summary: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.

Gene is located in Chromosome: 3

Location in Chromosome : 3q13.33

Description of this Gene: CD86 molecule

Type of Gene: protein-coding

rs2681416 in CD86 gene and Diffuse Large B-Cell Lymphoma PMID 25261932 2014 Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.

rs2715274 in CD86 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs9831894 in CD86 gene and Immunoglobulin A deficiency (disorder) PMID 27723758 2016 Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency.

rs2681416 in CD86 gene and Mature B-Cell Neoplasm PMID 25279986 2014 Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.

rs4308217 in CD86 gene and Multiple Sclerosis PMID 21833088 2011 Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

rs9831894 in CD86 gene and Selective immunoglobulin A deficiency PMID 27723758 2016 Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency.