Gene: DGKH

Alternate names for this Gene: DGKeta

Gene Summary: This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified.

Gene is located in Chromosome: 13

Location in Chromosome : 13q14.11

Description of this Gene: diacylglycerol kinase eta

Type of Gene: protein-coding

rs347412 in DGKH gene and Asthma PMID 25221879 2014 Genome-wide interrogation of longitudinal FEV1 in children with asthma.

rs1012053 in DGKH gene and Bipolar Disorder PMID 17486107 2008 A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.

rs12583267 in DGKH gene and Blood urea nitrogen measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs9533031 in DGKH gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs4142110 in DGKH gene and Calculus of kidney and ureter PMID 22396660 2012 A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.

rs1170109 in DGKH gene and Cortisol Measurement PMID 28843169 2017 The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels.

rs67332916 in DGKH gene and Creatinine measurement, serum (procedure) PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs9594674 in DGKH gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs9566910 in DGKH gene and Esophageal Neoplasms PMID 22960999 2012 Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.

rs347412 in DGKH gene and Forced expiratory volume function PMID 25221879 2014 Genome-wide interrogation of longitudinal FEV1 in children with asthma.

rs34445998 in DGKH gene and Glomerular Filtration Rate PMID 30604766 2019 Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.

PMID 31015462 2019 Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.

PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

rs4142110 in DGKH gene and Nephrolithiasis PMID 22396660 2012 Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14).

PMID 22396660 2012 A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.

rs347412 in DGKH gene and Respiratory Function Tests PMID 25221879 2014 Genome-wide interrogation of longitudinal FEV1 in children with asthma.

rs73187288 in DGKH gene and Systolic Pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

rs7328064 in DGKH gene and Urolithiasis PMID 30975718 2019 Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population.