Gene: DRD2

Alternate names for this Gene: D2DR|D2R

Gene Summary: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.

Gene is located in Chromosome: 11

Location in Chromosome : 11q23.2

Description of this Gene: dopamine receptor D2

Type of Gene: protein-coding

rs17601612 in DRD2 gene and Duration of sleep PMID 27992416 2017 Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits.

rs11214607 in DRD2 gene and Major Depressive Disorder PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs11214606 in DRD2 gene and Memory, Short-Term PMID 21107309 2011 Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.

rs11214607 in DRD2 gene and Mood Disorders PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs2734839 in DRD2 gene and Processing speed PMID 25869804 2016 GWAS for executive function and processing speed suggests involvement of the CADM2 gene.

rs1079596 in DRD2 gene and Triglycerides measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs7131440 in DRD2 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.