Gene: EPHB2

Alternate names for this Gene: BDPLT22|CAPB|DRT|EK5|EPHT3|ERK|Hek5|PCBC|Tyro5

Gene Summary: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.12

Description of this Gene: EPH receptor B2

Type of Gene: protein-coding

rs144045260 in EPHB2 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs138551214 in EPHB2 gene and Colorectal Neoplasms PMID 18682749 2008 Germline EPHB2 receptor variants in familial colorectal cancer.

rs67142165 in EPHB2 gene and Thyroxine measurement PMID 30843173 2019 Genome-wide meta-analysis identifies novel loci associated with free triiodothyronine and thyroid-stimulating hormone.

rs67142165 in EPHB2 gene and Triiodothyronine measurement PMID 30843173 2019 The EPHB2 gene variant rs67142165 reached genome-wide significance for association with fT3 plasma levels (P = 9.27 × 10<sup>-9</sup>) and its significance was confirmed in bivariate analysis (P = 9.72 × 10<sup>-9</sup>).