Xcode Life

Condition: Colorectal Neoplasms

rs4849303 in ACOXL gene and Colorectal Neoplasms

PMID 24743840 2014 Genome-wide diet-gene interaction analyses for risk of colorectal cancer.

rs11692435 in ACTR1B gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs35446936 in ACTRT3 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs1057519754 in AKT2 gene and Colorectal Neoplasms

PMID 16094359 2005 Colorectal cancer: mutations in a signalling pathway.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

rs121913326 in APC gene and Colorectal Neoplasms

PMID 24861525 2015 Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 22810696 2012 Comprehensive molecular characterization of human colon and rectal cancer.

PMID 1528264 1992 APC mutations occur early during colorectal tumorigenesis.

PMID 8187091 1994 Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

PMID 10737795 2000 "APC mutations in sporadic colorectal tumors: A mutational ""hotspot"" and interdependence of the ""two hits""."

PMID 1338904 1992 Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.

PMID 23204322 2012 A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.

PMID 24518971 2014 A unique profile of adenomatous polyposis coli gene mutations in Iranian patients suffering sporadic colorectal cancer.

PMID 17704924 2008 Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients.

PMID 18992635 2008 Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer.

PMID 23700467 2013 Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing.

PMID 21901162 2011 Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients.

PMID 2281069 1990 [The effect of occlusion time in the measurement of compliance and resistance of the respiratory system using passive expiration in infants].

PMID 12374230 2002 Mutations of the APC gene in human sporadic colorectal cancers.

PMID 24651453 2014 HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci.

PMID 22848674 2012 Comprehensive mutation analysis in colorectal flat adenomas.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs11169552 in ATF1 gene and Colorectal Neoplasms

PMID 20972440 2010 Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs597808 in ATXN2 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs1023835002 in B2M;PATL2 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1800469 in B9D2;TGFB1 gene and Colorectal Neoplasms

PMID 27145994 2016 Common genetic variation in ETV6 is associated with colorectal cancer susceptibility.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

rs12548629 in BAALC;BAALC-AS1 gene and Colorectal Neoplasms

PMID 29698419 2018 Genetic susceptibility markers for a breast-colorectal cancer phenotype: Exploratory results from genome-wide association studies.

rs4808075 in BABAM1;USHBP1 gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs4948317 in BICC1 gene and Colorectal Neoplasms

rs35107139 in BMP4 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs62404966 in BMP5 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs72942485 in BOC gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs113488022 in BRAF gene and Colorectal Neoplasms

PMID 12068308 2002 Mutations of the BRAF gene in human cancer.

PMID 23251002 2013 Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.

PMID 23549875 2013 Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.

PMID 19001320 2008 Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.

PMID 20413299 2010 Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab.

PMID 20857202 2011 BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis.

PMID 22448344 2012 EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib.

PMID 21426297 2011 BRAF as a target for cancer therapy.

PMID 22608338 2012 Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.

PMID 20350999 2010 Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery.

PMID 21129611 2010 Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?

PMID 23845441 2013 A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

PMID 23325582 2013 Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer.

PMID 22180495 2012 Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.

PMID 23812671 2013 Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth.

PMID 24107445 2013 Our findings indicated that proteasome inhibition might represent a valuable targeting strategy in BRAF V600E-mutant colorectal tumors.

PMID 21163703 2011 KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.

PMID 24163374 2014 mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.

PMID 22281684 2012 Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

PMID 20619739 2010 Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.

PMID 19537845 2009 Clinical biomarkers in oncology: focus on colorectal cancer.

PMID 25989278 2015 Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer.

PMID 24594804 2014 BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis.

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 22310681 2012 The road to resistance: EGFR mutation and cetuximab.

PMID 18186519 2008 Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD).

PMID 19794125 2009 Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.

PMID 21343559 2011 Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma.

PMID 19363522 2009 Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.

PMID 21190184 2011 Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma.

PMID 21716161 2011 BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis.

PMID 22535154 2012 Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma.

rs11571818 in BRCA2 gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs7742915 in BTBD9 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs3087967 in C11orf53 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs254563 in C5orf66 gene and Colorectal Neoplasms

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 23263487 2013 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs4976270 in C5orf66;LOC105379188 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs2427308 in CABLES2 gene and Colorectal Neoplasms

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

rs10505477 in CASC8;PCAT1;POU5F1B gene and Colorectal Neoplasms

PMID 17618283 2007 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs7014346 in CASC8;POU5F1B;PCAT1 gene and Colorectal Neoplasms

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

rs694339 in CBLN2 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs3217810 in CCND2 gene and Colorectal Neoplasms

PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

rs10774214 in CCND2-AS1 gene and Colorectal Neoplasms

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 23263487 2013 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs9929218 in CDH1 gene and Colorectal Neoplasms

PMID 19011631 2008 Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs9924886 in CDH3 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs1057519882 in CDKN2A gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1011970 in CDKN2B-AS1 gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs16845107 in CFAP44;CFAP44-AS1 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs145364999 in CHD1 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs4944940 in CHRDL2 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs11150038 in CLEC3A gene and Colorectal Neoplasms

PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs7993934 in COL4A2 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs3802842 in COLCA2;COLCA1 gene and Colorectal Neoplasms

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

PMID 21761138 2012 Meta-analysis of new genome-wide association studies of colorectal cancer risk.

PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

rs1057519884 in CREBBP gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs7495132 in CRTC3;CRTC3-AS1 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs1057519886 in CTNNB1 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs10904849 in CUBN gene and Colorectal Neoplasms

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

rs4919687 in CYP17A1 gene and Colorectal Neoplasms

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs4946260 in DCBLD1 gene and Colorectal Neoplasms

PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

rs77969132 in DENND5B gene and Colorectal Neoplasms

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

rs4768903 in DIP2B gene and Colorectal Neoplasms

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

rs17659990 in DOCK3 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs10457678 in ECT2L gene and Colorectal Neoplasms

PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs2070699 in EDN1 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs201395236 in EFCAB2 gene and Colorectal Neoplasms

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

rs1057519760 in EGFR gene and Colorectal Neoplasms

PMID 22270724 2012 Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer.

rs5753618 in EIF4ENIF1;DRG1 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs209489 in ELOVL5 gene and Colorectal Neoplasms

PMID 26586795 2016 Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis.

rs7692430 in EPHA5 gene and Colorectal Neoplasms

PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

rs138551214 in EPHB2 gene and Colorectal Neoplasms

PMID 18682749 2008 Germline EPHB2 receptor variants in familial colorectal cancer.

rs202110856 in ERAP1 gene and Colorectal Neoplasms

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

rs1057519816 in ERBB2 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1057519893 in ERBB3 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs2238126 in ETV6 gene and Colorectal Neoplasms

PMID 27145994 2016 Common genetic variation in ETV6 is associated with colorectal cancer susceptibility.

rs1535 in FADS2 gene and Colorectal Neoplasms

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs4246215 in FADS2;FEN1 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs6051080 in FAM182A gene and Colorectal Neoplasms

PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs13129679 in FAM193A;RNF4 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs1057519895 in FBXW7 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11200014 in FGFR2 gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs17816465 in FMN1 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs16959063 in FMN1;LOC107984089 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs56084662 in FRY gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs4143094 in GATA3 gene and Colorectal Neoplasms

PMID 24743840 2014 Genome-wide diet-gene interaction analyses for risk of colorectal cancer.

rs1057941 in GBAP1 gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs11554273 in GNAS gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

rs3753366 in GNG12 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs7252505 in GPATCH1 gene and Colorectal Neoplasms

PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

rs5934683 in GPR143 gene and Colorectal Neoplasms

PMID 22634755 2012 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

rs2293581 in GREM1;LOC100131315 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs3131043 in HCG20 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs12916300 in HERC2 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs11727676 in HHIP gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs115392158 in HLA-B gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs1362126 in HLA-F gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs12601991 in HNF1B gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs104894230 in HRAS;LRRC56 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1665650 in HSPA12A gene and Colorectal Neoplasms

PMID 23263487 2013 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.

rs121913499 in IDH1 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1057519906 in IDH2 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11119608 in KCNH1 gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs16869961 in KCNIP4 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs28541881 in KIAA0355 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs45597035 in KLF5 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs1057519725 in KRAS gene and Colorectal Neoplasms

PMID 20921462 2010 Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer.

PMID 21228335 2011 Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

PMID 19114683 2009 Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer.

PMID 19679400 2009 Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.

PMID 20921465 2010 Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study.

PMID 16361624 2005 Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma.

PMID 18316791 2008 Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.

PMID 16618717 2006 KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

PMID 26623049 2015 Cetuximab treatment for metastatic colorectal cancer with KRAS p.G13D mutations improves progression-free survival.

PMID 21398618 2011 Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations.

PMID 20978259 2010 Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab.

PMID 23182985 2013 Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab.

PMID 22734028 2012 Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab.

PMID 24558511 2014 KRAS G13D Mutation and Sensitivity to Cetuximab or Panitumumab in a Colorectal Cancer Cell Line Model.

PMID 22392911 2012 Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 19881948 2009 BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells.

PMID 22722830 2012 Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 23325582 2013 Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer.

rs73110464 in KRT8 gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs7542665 in L1TD1 gene and Colorectal Neoplasms

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

rs1741640 in LAMA5 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 20972440 2010 Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.

rs10911251 in LAMC1 gene and Colorectal Neoplasms

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs34245511 in LIMA1 gene and Colorectal Neoplasms

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

rs1330889 in LINC00446;OBI1-AS1 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs983318 in LINC00511;LINC00673 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs6720296 in LINC01121 gene and Colorectal Neoplasms

PMID 25866641 2015 A genome wide association study on Newfoundland colorectal cancer patients' survival outcomes.

rs7606512 in LINC01173 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs12412391 in LINC01475 gene and Colorectal Neoplasms

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

rs17094983 in LINC01500 gene and Colorectal Neoplasms

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs17011141 in LINC02257 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs2293582 in LOC100131315;GREM1 gene and Colorectal Neoplasms

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs73975586 in LOC101927727;NXN gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs11085466 in LOC101929007 gene and Colorectal Neoplasms

PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs16973225 in LOC102724001 gene and Colorectal Neoplasms

PMID 25781442 2015 Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.

rs10849433 in LOC105369624 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs10849432 in LOC105369625 gene and Colorectal Neoplasms

rs7300312 in LOC105370003 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs1570405 in LOC105370507 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs143046984 in LOC105370557;PCNX1 gene and Colorectal Neoplasms

PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

rs4811050 in LOC105372657 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs2184857 in LOC105373224 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs11884596 in LOC105373831 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs13020391 in LOC105373881;PNKD gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs4147045 in LOC105374510 gene and Colorectal Neoplasms

PMID 24743840 2014 Genome-wide diet-gene interaction analyses for risk of colorectal cancer.

rs2450115 in LOC105375712 gene and Colorectal Neoplasms

rs10795668 in LOC105376400 gene and Colorectal Neoplasms

PMID 18372905 2008 A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs35470271 in LOC105377043 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs75316749 in LOC107986051 gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs9409565 in LOC107987100 gene and Colorectal Neoplasms

PMID 27723779 2016 Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer.

rs75954926 in LOC107987251 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs16878812 in LOC112267956;FKBP5 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs117079142 in LOC112268030;UTP23 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs16944613 in LOC112268163;CRTC3 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs742223 in LOC340184 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs10980628 in LPAR1 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs812481 in LRIG1 gene and Colorectal Neoplasms

PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

rs4759277 in LRP1 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs7398375 in LRP1-AS;LRP1 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs104894226 in LRRC56;HRAS gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 16478791 2006 APC inhibits ERK pathway activation and cellular proliferation induced by RAS.

rs4378954 in LSAMP gene and Colorectal Neoplasms

PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs658191 in MACF1 gene and Colorectal Neoplasms

PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

rs12979278 in MAMSTR gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs1057519728 in MAP2K1 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs2516420 in MICB-DT gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs1057519738 in MIR4728;ERBB2 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs142319636 in MMP2 gene and Colorectal Neoplasms

PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

rs1057519917 in MTOR gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs2974935 in MTX1 gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs10936599 in MYNN gene and Colorectal Neoplasms

PMID 20972440 2010 Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.

rs9583269 in MYO16 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs174533 in MYRF;TMEM258 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs73068325 in MZF1-AS1;MZF1 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs481519 in NEK10 gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs73208120 in NOS1 gene and Colorectal Neoplasms

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

rs3830041 in NOTCH4 gene and Colorectal Neoplasms

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

rs11554290 in NRAS gene and Colorectal Neoplasms

PMID 20736745 2010 NRAS mutations are rare in colorectal cancer.

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 21305640 2011 Frequency of KRAS, BRAF, and NRAS mutations in colorectal cancer.

PMID 17699718 2007 AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models.

PMID 21729679 2011 Development of molecular biomarkers in individualized treatment of colorectal cancer.

PMID 20619739 2010 Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.

PMID 16273091 2006 BRAF mutation predicts sensitivity to MEK inhibition.

PMID 21829508 2011 PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

rs12603526 in NXN gene and Colorectal Neoplasms

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs4836891 in OR1J2 gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs1057519879 in PATL2;B2M gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs6983267 in PCAT1;CCAT2;CASC8;POU5F1B gene and Colorectal Neoplasms

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 21242260 2011 Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

PMID 18372905 2008 A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 17618284 2007 A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.

PMID 30104761 2018 Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

rs2286313 in PCNX1 gene and Colorectal Neoplasms

PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

rs6058093 in PIGU gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs104886003 in PIK3CA gene and Colorectal Neoplasms

PMID 20619739 2010 Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.

PMID 15254419 2004 The PIK3CA gene is mutated with high frequency in human breast cancers.

PMID 22162589 2012 Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.

PMID 22162582 2012 Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials.

PMID 19903786 2009 PIK3CA mutations predict local recurrences in rectal cancer patients.

PMID 19223544 2009 PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies.

PMID 15647370 2005 Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.

PMID 19366826 2009 PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer.

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 20453058 2010 Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.

PMID 18725974 2008 Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

PMID 15016963 2004 High frequency of mutations of the PIK3CA gene in human cancers.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 22357840 2012 Prognostic role of PIK3CA mutation in colorectal cancer: cohort study and literature review.

PMID 24559322 2014 Regorafenib in metastatic colorectal cancer.

PMID 15930273 2005 Functional analysis of PIK3CA gene mutations in human colorectal cancer.

rs1057519841 in PIK3R1 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs114436839 in PLCH1 gene and Colorectal Neoplasms

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs2250430 in PLEKHG6 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs3731861 in PNKD;CATIP-AS2 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs3824999 in POLD3 gene and Colorectal Neoplasms

PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

PMID 22634755 2012 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs1057519943 in POLE gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs7013278 in POU5F1B;CCAT2;CASC8;PCAT1 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs12682374 in POU5F1B;PCAT1;CCAT2;CASC8 gene and Colorectal Neoplasms

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs7606562 in PPP1R21 gene and Colorectal Neoplasms

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

rs1057519946 in PPP2R1A gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs6066825 in PREX1 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

rs1057519724 in PTEN gene and Colorectal Neoplasms

PMID 22162582 2012 Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials.

PMID 20453058 2010 Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.

PMID 20619739 2010 Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.

PMID 22162589 2012 Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.

PMID 15647370 2005 Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.

PMID 15016963 2004 High frequency of mutations of the PIK3CA gene in human cancers.

PMID 19366826 2009 PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer.

PMID 19903786 2009 PIK3CA mutations predict local recurrences in rectal cancer patients.

PMID 18725974 2008 Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

PMID 15254419 2004 The PIK3CA gene is mutated with high frequency in human breast cancers.

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121918464 in PTPN11 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11844632 in RAD51B gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs80338796 in RAF1 gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs2300206 in RALY gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs9901225 in RETREG3 gene and Colorectal Neoplasms

PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs1057519952 in RHOA gene and Colorectal Neoplasms

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs10411210 in RHPN2 gene and Colorectal Neoplasms

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 19011631 2008 Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs6091189 in RIPOR3 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs17503919 in RNGTT gene and Colorectal Neoplasms

PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs3787089 in RTEL1-TNFRSF6B;RTEL1 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs2738783 in RTEL1;RTEL1-TNFRSF6B gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs4450168 in SBF2 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs7740797 in SCAF8 gene and Colorectal Neoplasms

PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs4360494 in SF3A3 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs3184504 in SH2B3;ATXN2 gene and Colorectal Neoplasms

PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

rs2732875 in SHROOM2 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs9481067 in SLC22A16 gene and Colorectal Neoplasms

PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs7758229 in SLC22A3 gene and Colorectal Neoplasms

PMID 21242260 2011 Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.

rs6781752 in SLC25A26 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs77776598 in SLC6A18 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs10049390 in SLCO2A1 gene and Colorectal Neoplasms

rs56324967 in SMAD3 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs1057519739 in SMAD4 gene and Colorectal Neoplasms

PMID 8898652 1996 Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.

PMID 17994767 2007 Novel mutations in Smad proteins that inhibit signaling by the transforming growth factor beta in mammalian cells.

PMID 12821112 2003 Role of Smad4 (DPC4) inactivation in human cancer.

PMID 9679244 1998 TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

PMID 14715079 2004 Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.

PMID 10775259 2000 Transcriptional control by the TGF-beta/Smad signaling system.

PMID 10479724 1999 Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs12594720 in SMAD6 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs11874392 in SMAD7 gene and Colorectal Neoplasms

PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

PMID 21761138 2012 Meta-analysis of new genome-wide association studies of colorectal cancer risk.

PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 17934461 2007 A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

PMID 30104761 2018 Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

PMID 24448986 2014 Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

rs12427600 in SMAD9 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs11064437 in SPSB2 gene and Colorectal Neoplasms

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs377429877 in STARD13 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs56848936 in SYMPK gene and Colorectal Neoplasms

PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

rs448513 in TANC1 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs59336 in TBX3 gene and Colorectal Neoplasms

PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

rs11196170 in TCF7L2 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs3181245 in TDP2 gene and Colorectal Neoplasms

PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs1028166 in TENM3;TENM3-AS1 gene and Colorectal Neoplasms

PMID 25192705 2014 No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.

rs2735940 in TERT gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs1391441 in TET2-AS1;TET2 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs4711689 in TFEB gene and Colorectal Neoplasms

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs992157 in TMBIM1;PNKD gene and Colorectal Neoplasms

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

rs1078643 in TMEM220-AS1;TMEM238L gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

rs174537 in TMEM258;MYRF gene and Colorectal Neoplasms

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

rs9797885 in TMEM91 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs1963413 in TMEM91;B9D2 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs2052678 in TMTC1 gene and Colorectal Neoplasms

PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs3801081 in TNS3 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs2179593 in TOX2 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs1057519747 in TP53 gene and Colorectal Neoplasms

rs2186607 in TRPC6 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs12143541 in TTC22 gene and Colorectal Neoplasms

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs11168936 in TUBA1C gene and Colorectal Neoplasms

PMID 27197191 2016 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

rs76316943 in UTP23 gene and Colorectal Neoplasms

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

rs10506868 in VTI1A gene and Colorectal Neoplasms

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PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 25105248 2014 Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs1912804 in WWOX gene and Colorectal Neoplasms

PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs1057520009 in XPO1 gene and Colorectal Neoplasms

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rs10511330 in ZBTB20 gene and Colorectal Neoplasms

PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs1250567 in ZMIZ1 gene and Colorectal Neoplasms

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs704017 in ZMIZ1-AS1 gene and Colorectal Neoplasms

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

rs12646351 in ZNF827 gene and Colorectal Neoplasms

PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.