Gene: KCNIP4

Alternate names for this Gene: CALP|KCHIP4

Gene Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Gene is located in Chromosome: 4

Location in Chromosome : 4p15.31-p15.2

Description of this Gene: potassium voltage-gated channel interacting protein 4

Type of Gene: protein-coding

rs16869961 in KCNIP4 gene and Adenocarcinoma of large intestine PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs6826348 in KCNIP4 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs147627531 in KCNIP4 gene and Aspartate aminotransferase measurement PMID 30589442 2019 Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.

rs10019221 in KCNIP4 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs16869961 in KCNIP4 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs16869961 in KCNIP4 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs16869961 in KCNIP4 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs16869961 in KCNIP4 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs16869961 in KCNIP4 gene and Colorectal Carcinoma PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs16869961 in KCNIP4 gene and Colorectal Neoplasms PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs2874890 in KCNIP4 gene and Diverticular Diseases PMID 30177863 2018 Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease.

rs145272881 in KCNIP4 gene and Interleukin 13 Measurement PMID 27989323 2017 Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.

rs16869961 in KCNIP4 gene and Malignant neoplasm of large intestine PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs16869961 in KCNIP4 gene and Malignant tumor of colon PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs141863958 in KCNIP4 gene and Parkinson Disease PMID 25663231 2015 PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

rs6826348 in KCNIP4 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs1949226 in KCNIP4 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

rs1495509 in KCNIP4 gene and response to ACE inhibitor PMID 26169577 2016 A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough.