Gene: WWOX

Alternate names for this Gene: D16S432E|DEE28|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1

Gene Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 16

Location in Chromosome : 16q23.1-q23.2

Description of this Gene: WW domain containing oxidoreductase

Type of Gene: protein-coding

rs1912804 in WWOX gene and Adenocarcinoma of large intestine PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs34592201 in WWOX gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs2738696 in WWOX gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1912804 in WWOX gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs1912804 in WWOX gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs1912804 in WWOX gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs1912804 in WWOX gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs1912804 in WWOX gene and Colorectal Carcinoma PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs1912804 in WWOX gene and Colorectal Neoplasms PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs587777248 in WWOX gene and EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1 PMID 24456803 2014 The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.

rs4887991 in WWOX gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs8057779 in WWOX gene and Esophageal Neoplasms PMID 22960999 2012 Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.

rs12716850 in WWOX gene and Forced expiratory volume function PMID 23284291 2012 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.

PMID 21946350 2011 Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

rs2134995 in WWOX gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs1912804 in WWOX gene and Malignant neoplasm of large intestine PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs1912804 in WWOX gene and Malignant tumor of colon PMID 29228715 2017 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.

rs12149527 in WWOX gene and Multiple Sclerosis PMID 24076602 2013 Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

rs9923451 in WWOX gene and Obesity PMID 21552555 2011 A genome-wide association study on obesity and obesity-related traits.

rs12445943 in WWOX gene and Peripheral Arterial Diseases PMID 27082954 2016 Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.

rs12716852 in WWOX gene and Pulmonary function PMID 21946350 2011 Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

rs12716852 in WWOX gene and Pulmonary function (finding) PMID 21946350 2011 Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

rs17706989 in WWOX gene and Reasoning PMID 21107309 2011 Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.

rs1110544 in WWOX gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs12716850 in WWOX gene and Respiratory Function Tests PMID 23284291 2012 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.

PMID 21946350 2011 Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

rs34592201 in WWOX gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs587777128 in WWOX gene and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 12 PMID 24456803 2014 The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.

PMID 24369382 2014 The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.

PMID 25411445 2015 WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation.

rs113496184 in WWOX gene and Smoking PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs113496184 in WWOX gene and Smoking Behaviors PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs1875939 in WWOX gene and Venous Thromboembolism PMID 28203683 2017 Identification of unique venous thromboembolism-susceptibility variants in African-Americans.

rs1079572 in WWOX gene and Vital capacity PMID 24929828 2014 Genome-wide association analysis identifies six new loci associated with forced vital capacity.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

rs7500549 in WWOX gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

rs2345443 in WWOX gene and peak expiratory flow (procedure) PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

rs2047925 in WWOX gene and response to bronchodilator PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.