Gene: EPHA5

Alternate names for this Gene: CEK7|EHK-1|EHK1|EK7|HEK7|TYRO4

Gene Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene is located in Chromosome: 4

Location in Chromosome : 4q13.1-q13.2

Description of this Gene: EPH receptor A5

Type of Gene: protein-coding

rs7692430 in EPHA5 gene and Adenocarcinoma of large intestine PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

rs1057520012 in EPHA5 gene and Adenocarcinoma of lung (disorder) PMID 16140923 2005 Somatic mutations of the protein kinase gene family in human lung cancer.

rs28535294 in EPHA5 gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11735820 in EPHA5 gene and Asthma PMID 21804549 2011 Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.

rs7692430 in EPHA5 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

rs7692430 in EPHA5 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

rs7692430 in EPHA5 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

rs7692430 in EPHA5 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

rs7692430 in EPHA5 gene and Colorectal Carcinoma PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

rs7692430 in EPHA5 gene and Colorectal Neoplasms PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

rs7692430 in EPHA5 gene and Dermatologic disorders PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

rs13145146 in EPHA5 gene and Intelligence PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs7692430 in EPHA5 gene and Malignant neoplasm of large intestine PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

rs7692430 in EPHA5 gene and Malignant tumor of colon PMID 30557370 2018 Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

rs13145146 in EPHA5 gene and Schizophrenia PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs60178806 in EPHA5 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.