Gene: TBX3

Alternate names for this Gene: TBX3-ISO|UMS|XHL

Gene Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.

Gene is located in Chromosome: 12

Location in Chromosome : 12q24.21

Description of this Gene: T-box transcription factor 3

Type of Gene: protein-coding

rs59336 in TBX3 gene and Adenocarcinoma of large intestine PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

rs8853 in TBX3 gene and Benign Prostatic Hyperplasia PMID 30410027 2018 Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.

rs1061651 in TBX3 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs59336 in TBX3 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

rs59336 in TBX3 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

rs59336 in TBX3 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

rs59336 in TBX3 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

rs551510 in TBX3 gene and Colorectal Carcinoma PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

rs59336 in TBX3 gene and Colorectal Neoplasms PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

rs8853 in TBX3 gene and Lower Urinary Tract Symptoms PMID 30410027 2018 Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.

rs59336 in TBX3 gene and Malignant neoplasm of large intestine PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

rs59336 in TBX3 gene and Malignant tumor of colon PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.