Gene: ZBTB20

Alternate names for this Gene: DPZF|HOF|ODA-8S|PRIMS|ZNF288

Gene Summary: This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene is located in Chromosome: 3

Location in Chromosome : 3q13.31

Description of this Gene: zinc finger and BTB domain containing 20

Type of Gene: protein-coding

rs10511330 in ZBTB20 gene and Adenocarcinoma of large intestine PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs7643617 in ZBTB20 gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs139459337 in ZBTB20 gene and Bipolar Disorder PMID 30217971 2018 Genome-wide association study of seasonal affective disorder.

rs2399510 in ZBTB20 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs17619973 in ZBTB20 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs10511330 in ZBTB20 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs10511330 in ZBTB20 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs10511330 in ZBTB20 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs10511330 in ZBTB20 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs10511330 in ZBTB20 gene and Colorectal Carcinoma PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs10511330 in ZBTB20 gene and Colorectal Mucinous Adenocarcinoma PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs10511330 in ZBTB20 gene and Colorectal Neoplasms PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs10804515 in ZBTB20 gene and Height PMID 17767157 2007 A common variant of HMGA2 is associated with adult and childhood height in the general population.

rs139459337 in ZBTB20 gene and Major Depressive Disorder PMID 30217971 2018 Genome-wide association study of seasonal affective disorder.

rs10511330 in ZBTB20 gene and Malignant neoplasm of large intestine PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs9841504 in ZBTB20 gene and Malignant neoplasm of stomach PMID 22037551 2011 We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)).

rs10511330 in ZBTB20 gene and Malignant tumor of colon PMID 29942513 2018 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

rs483353068 in ZBTB20 gene and Primrose syndrome PMID 25017102 2014 Mutations in ZBTB20 cause Primrose syndrome.

rs9841504 in ZBTB20 gene and Schizophrenia PMID 22037555 2011 Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.

rs9841504 in ZBTB20 gene and Stomach Carcinoma PMID 22037551 2011 We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)).

rs1882289 in ZBTB20 gene and Systolic Pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

rs139459337 in ZBTB20 gene and Unipolar Depression PMID 30217971 2018 Genome-wide association study of seasonal affective disorder.