Gene: POLD3
Alternate names for this Gene: P66|P68|PPP1R128
Gene Summary: This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene.
Gene is located in Chromosome: 11
Location in Chromosome : 11q13.4
Description of this Gene: DNA polymerase delta 3, accessory subunit
Type of Gene: protein-coding
rs3824999 in
POLD3 gene and
Adenocarcinoma of large intestine
PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
PMID 22634755 2012 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs7121958 in
POLD3 gene and
Adenoma of large intestine
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs7929392 in
POLD3 gene and
Body Height
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs3824999 in
POLD3 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
PMID 22634755 2012 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs3824999 in
POLD3 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
PMID 22634755 2012 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs3824999 in
POLD3 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
PMID 22634755 2012 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs3824999 in
POLD3 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
PMID 22634755 2012 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs3824999 in
POLD3 gene and
Colorectal Carcinoma
PMID 22634755 2012 We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.
PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs3824999 in
POLD3 gene and
Colorectal Neoplasms
PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
PMID 22634755 2012 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs4420291 in
POLD3 gene and
Diastolic blood pressure
PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
rs3824999 in
POLD3 gene and
Malignant neoplasm of large intestine
PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
PMID 22634755 2012 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs3824999 in
POLD3 gene and
Malignant tumor of colon
PMID 26151821 2015 Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
PMID 29917119 2019 Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
PMID 22634755 2012 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.