Gene: FCRL3

Alternate names for this Gene: CD307c|FCRH3|IFGP3|IRTA3|SPAP2

Gene Summary: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 1

Location in Chromosome : 1q23.1

Description of this Gene: Fc receptor like 3

Type of Gene: protein-coding

rs7528684 in FCRL3 gene and Autoantibody measurement PMID 21829393 2011 Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

rs7522061 in FCRL3 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs7528684 in FCRL3 gene and Diabetes Mellitus, Insulin-Dependent PMID 21829393 2011 Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

rs3761959 in FCRL3 gene and Graves Disease PMID 21841780 2011 A genome-wide association study identifies two new risk loci for Graves' disease.

rs11264799 in FCRL3 gene and IGA Glomerulonephritis PMID 26028593 2015 Identification of new susceptibility loci for IgA nephropathy in Han Chinese.

rs2210913 in FCRL3 gene and Immunoglobulin A deficiency (disorder) PMID 27723758 2016 Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency.

rs3761959 in FCRL3 gene and Low density lipoprotein cholesterol measurement PMID 26920376 2016 Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.

rs3761959 in FCRL3 gene and Multiple Sclerosis PMID 26920376 2016 Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.

rs3761959 in FCRL3 gene and Rheumatoid Arthritis PMID 24532676 2015 High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.

rs2210913 in FCRL3 gene and Selective immunoglobulin A deficiency PMID 27723758 2016 Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency.

rs11264794 in FCRL3 gene and White Blood Cell Count procedure PMID 21738479 2011 Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).