Gene: FRMD3

Alternate names for this Gene: 4.1O|EPB41L4O|EPB41LO|P410

Gene Summary: The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 9

Location in Chromosome : 9q21.32

Description of this Gene: FERM domain containing 3

Type of Gene: protein-coding

rs11140055 in FRMD3 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10868025 in FRMD3 gene and Diabetic Nephropathy PMID 19252134 2009 Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes.

rs115795127 in FRMD3 gene and Diastolic blood pressure PMID 28498854 2017 Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

rs115795127 in FRMD3 gene and Hypertensive disease PMID 28498854 2017 Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

rs190601686 in FRMD3 gene and Prostate carcinoma PMID 31095341 2020 Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy.

rs115795127 in FRMD3 gene and Systolic Pressure PMID 28498854 2017 Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.