Gene: MGAT5

Alternate names for this Gene: GNT-V|GNT-VA|MGAT5A|glcNAc-T V

Gene Summary: The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies.

Gene is located in Chromosome: 2

Location in Chromosome : 2q21.2-q21.3

Description of this Gene: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase

Type of Gene: protein-coding

rs2593704 in MGAT5 gene and Alkaline phosphatase measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs1257168 in MGAT5 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs1439112 in MGAT5 gene and Chronic Lymphocytic Leukemia PMID 31407831 2019 Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.

rs1257192 in MGAT5 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11887156 in MGAT5 gene and Lupus Erythematosus, Systemic PMID 28714469 2017 Transancestral mapping and genetic load in systemic lupus erythematosus.

PMID 31407831 2019 Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.

rs1439112 in MGAT5 gene and Marginal Zone B-Cell Lymphoma PMID 31407831 2019 Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.

rs4953911 in MGAT5 gene and Multiple Sclerosis PMID 20117844 2010 MGAT5 alters the severity of multiple sclerosis.

rs1439112 in MGAT5 gene and Small Lymphocytic Lymphoma PMID 31407831 2019 Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.