Gene: MICB

Alternate names for this Gene: PERB11.2

Gene Summary: This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: MHC class I polypeptide-related sequence B

Type of Gene: protein-coding

rs2534657 in MICB gene and ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs2534657 in MICB gene and AIDS, PROGRESSION TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs9378160 in MICB gene and Alcohol-Induced Disorders PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

rs9378160 in MICB gene and Alcohol-Related Disorders PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

rs9378160 in MICB gene and Alcoholic Intoxication, Chronic PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

rs2855812 in MICB gene and Asthma PMID 29273806 2018 Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

PMID 31619474 2019 Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.

rs3093953 in MICB gene and Behcet Syndrome PMID 23001997 2012 Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.

rs2855812 in MICB gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs2855812 in MICB gene and Childhood asthma PMID 31619474 2019 Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.

rs3132468 in MICB gene and Dengue Shock Syndrome PMID 22001756 2011 Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.

rs2246618 in MICB gene and Diabetes Mellitus, Insulin-Dependent PMID 17632545 2007 A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

rs2855812 in MICB gene and Forced expiratory volume function PMID 21946350 2011 Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

rs2534657 in MICB gene and HIV-1, RESISTANCE TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs2534657 in MICB gene and HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs2534657 in MICB gene and Hodgkin Disease PMID 24149102 2013 Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.

rs2855812 in MICB gene and Lupus Erythematosus, Systemic PMID 24871463 2014 GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.

rs2855812 in MICB gene and Major Depressive Disorder PMID 31619474 2019 Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.

rs2855812 in MICB gene and Myasthenia Gravis PMID 23055271 2012 Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.

rs3130614 in MICB gene and Myositis PMID 26291516 2015 Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.

rs2246618 in MICB gene and Pemphigus Vulgaris PMID 22437316 2012 Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris.

rs2855812 in MICB gene and Polybrominated biphenyl measurement PMID 28235828 2017 Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants.

rs2855812 in MICB gene and Pulmonary function PMID 21946350 2011 Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

rs2855812 in MICB gene and Pulmonary function (finding) PMID 21946350 2011 Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

rs2855812 in MICB gene and Respiratory Function Tests PMID 21946350 2011 Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

rs2855812 in MICB gene and Rheumatoid Arthritis PMID 19503088 2009 REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

rs3132468 in MICB gene and Severe Dengue PMID 22001756 2011 Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.