Gene: OR12D3

Alternate names for this Gene: hs6M1-27

Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.1

Description of this Gene: olfactory receptor family 12 subfamily D member 3

Type of Gene: protein-coding

Gene: OR5V1

Alternate names for this Gene: 6M1-21|hs6M1-21

Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.1

Description of this Gene: olfactory receptor family 5 subfamily V member 1

Type of Gene: protein-coding

rs3749971 in OR12D3;OR5V1 gene and Acquired Immunodeficiency Syndrome PMID 19115949 2009 Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).

rs9257809 in OR12D3;OR5V1 gene and Adenocarcinoma Of Esophagus PMID 27527254 2016 Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis.

rs9257809 in OR12D3;OR5V1 gene and Barrett Esophagus PMID 27527254 2016 Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis.

PMID 22961001 2012 Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.

rs9257809 in OR12D3;OR5V1 gene and Body mass index procedure PMID 22982992 2012 FTO genotype is associated with phenotypic variability of body mass index.

rs9257809 in OR12D3;OR5V1 gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs115937317 in OR12D3;OR5V1 gene and Child Development Disorders, Pervasive PMID 28540026 2017 Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.

rs9257809 in OR12D3;OR5V1 gene and Diabetes Mellitus, Insulin-Dependent PMID 17632545 2007 A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

rs9257809 in OR12D3;OR5V1 gene and Finding of body mass index PMID 22982992 2012 FTO genotype is associated with phenotypic variability of body mass index.

rs3749971 in OR12D3;OR5V1 gene and Intelligence PMID 29942086 2018 Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

rs3749971 in OR12D3;OR5V1 gene and Lupus Erythematosus, Systemic PMID 24871463 2014 GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.

rs3749971 in OR12D3;OR5V1 gene and Malignant neoplasm of lung PMID 22899653 2012 Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.

rs9257809 in OR12D3;OR5V1 gene and Sarcoidosis PMID 26651848 2016 High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences.

rs114071887 in OR12D3;OR5V1 gene and Schizophrenia PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

PMID 28540026 2017 Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.