Gene: PDE11A

Alternate names for this Gene: PPNAD2

Gene Summary: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 2

Location in Chromosome : 2q31.2

Description of this Gene: phosphodiesterase 11A

Type of Gene: protein-coding

Gene: PDE11A-AS1

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 2

Location in Chromosome : 2q31.2

Description of this Gene: PDE11A antisense RNA 1

Type of Gene: ncRNA

rs13428806 in PDE11A;PDE11A-AS1 gene and Asthma PMID 20920776 2010 PDE11A associations with asthma: results of a genome-wide association scan.

rs17400325 in PDE11A;PDE11A-AS1 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs4893980 in PDE11A;PDE11A-AS1 gene and Diastolic blood pressure PMID 29212154 2017 Detection of susceptibility loci on APOA5 and COLEC12 associated with metabolic syndrome using a genome-wide association study in a Taiwanese population.

rs17400325 in PDE11A;PDE11A-AS1 gene and Myopia PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.