Gene: PTPN9
Alternate names for this Gene: MEG2|PTPMEG2
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis.
Gene is located in Chromosome: 15
Location in Chromosome : 15q24.2
Description of this Gene: protein tyrosine phosphatase non-receptor type 9
Type of Gene: protein-coding
rs11639183 in
PTPN9 gene and
Body Height
PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.
PMID 20189936 2010 A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
PMID 29782485 2018 Evaluation and application of summary statistic imputation to discover new height-associated loci.
PMID 25429064 2015 Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs8027365 in
PTPN9 gene and
Breast Carcinoma
PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.
rs4886707 in
PTPN9 gene and
Height
PMID 20189936 2010 A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.