Gene: SIRPG

Alternate names for this Gene: CD172g|SIRP-B2|SIRPB2|SIRPgamma|bA77C3.1

Gene Summary: The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene is located in Chromosome: 20

Location in Chromosome : 20p13

Description of this Gene: signal regulatory protein gamma

Type of Gene: protein-coding

rs2281808 in SIRPG gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs2281808 in SIRPG gene and Diabetes Mellitus, Insulin-Dependent PMID 19430480 2009 Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

rs2281808 in SIRPG gene and Multiple Sclerosis PMID 22190364 2011 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.