Gene: SLC15A2

Alternate names for this Gene: PEPT2

Gene Summary: The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011].

Gene is located in Chromosome: 3

Location in Chromosome : 3q13.33

Description of this Gene: solute carrier family 15 member 2

Type of Gene: protein-coding

rs75557865 in SLC15A2 gene and Allergic Reaction PMID 29083406 2017 Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.

rs2293616 in SLC15A2 gene and Eczema PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2250065 in SLC15A2 gene and Glomerular Filtration Rate PMID 31015462 2019 Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.

PMID 30604766 2019 Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.

PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 31451708 2019 Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program.

PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

rs4285028 in SLC15A2 gene and High density lipoprotein measurement PMID 26920376 2016 Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.

rs4285028 in SLC15A2 gene and Multiple Sclerosis PMID 21833088 2011 Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

PMID 26920376 2016 Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.