Gene: TENM4

Alternate names for this Gene: Doc4|ETM5|ODZ4|TEN4|TNM4|Ten-M4|ten-4

Gene Summary: The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5.

Gene is located in Chromosome: 11

Location in Chromosome : 11q14.1

Description of this Gene: teneurin transmembrane protein 4

Type of Gene: protein-coding

rs12576775 in TENM4 gene and Attention deficit hyperactivity disorder PMID 23453885 2013 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

rs10501439 in TENM4 gene and Bipolar Disorder PMID 24618891 2014 Genome-wide association study reveals two new risk loci for bipolar disorder.

PMID 21926972 2011 Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.

PMID 23453885 2013 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

PMID 23070075 2013 Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.

PMID 28115744 2018 A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder.

PMID 22182935 2013 Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.

rs1151200 in TENM4 gene and Birth Weight PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

rs2187172 in TENM4 gene and Carcinoma of lung PMID 28604730 2017 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

rs12576775 in TENM4 gene and Child Development Disorders, Pervasive PMID 23453885 2013 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

rs10501434 in TENM4 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs12576775 in TENM4 gene and Major Depressive Disorder PMID 23453885 2013 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

rs1151200 in TENM4 gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

rs12576775 in TENM4 gene and Schizophrenia PMID 23453885 2013 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

rs201191369 in TENM4 gene and TREMOR, HEREDITARY ESSENTIAL, 5 PMID 26188006 2015 Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor.

rs12275127 in TENM4 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.