Gene: WDPCP

Alternate names for this Gene: BBS15|C2orf86|CHDTHP|CPLANE5|FRITZ|FRTZ

Gene Summary: This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 2

Location in Chromosome : 2p15

Description of this Gene: WD repeat containing planar cell polarity effector

Type of Gene: protein-coding

rs6736411 in WDPCP gene and Asthma PMID 31619474 2019 Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.

rs6736411 in WDPCP gene and Attention deficit hyperactivity disorder PMID 31619474 2019 Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.

rs10209140 in WDPCP gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs186133190 in WDPCP gene and Cutaneous Melanoma PMID 26237428 2015 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.

rs62177792 in WDPCP gene and Eczema PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs186133190 in WDPCP gene and Malignant melanoma of skin of lower limb PMID 26237428 2015 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.

rs186133190 in WDPCP gene and Malignant melanoma of skin of upper limb PMID 26237428 2015 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.

rs2138798 in WDPCP gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

rs114780236 in WDPCP gene and Prostate carcinoma PMID 31562322 2019 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.

rs144528474 in WDPCP gene and Smoking PMID 30643258 2019 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

rs112028067 in WDPCP gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11125949 in WDPCP gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.