Gene: WDR36

Alternate names for this Gene: GLC1G|TA-WDRP|TAWDRP|UTP21

Gene Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG).

Gene is located in Chromosome: 5

Location in Chromosome : 5q22.1

Description of this Gene: WD repeat domain 36

Type of Gene: protein-coding

rs10038058 in WDR36 gene and Allergic Reaction PMID 23817569 2013 A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

rs1043828 in WDR36 gene and Asthma PMID 21907864 2011 Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.

rs55905691 in WDR36 gene and Blood basophil count (lab test) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs10045577 in WDR36 gene and Eosinophil count procedure PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

PMID 19198610 2009 Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.

rs549211166 in WDR36 gene and Glaucoma 1, Open Angle, G PMID 15677485 2005 Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1.

PMID 18172102 2008 Profiling of WDR36 missense variants in German patients with glaucoma.