Variant: rs429358 

    present in Gene: APOE
    present in Chromosome: 19
    Position on Chromosome: 44908684
    Alleles of this Variant: T/C

rs429358 in APOE gene and Age related macular degeneration PMID 26691988 2016 A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

rs429358 in APOE gene and Alzheimer Disease, Early Onset PMID 10799751 2000 Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease.

PMID 22381401 2012 Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: a meta-analysis.

PMID 23060451 2012 APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

PMID 9343467 1997 Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.

PMID 19605830 2009 Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect.

PMID 23296339 2013 Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.

PMID 23571587 2013 Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.

PMID 27260402 2016 Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians.

rs429358 in APOE gene and Alzheimer's Disease PMID 25027320 2014 SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.

PMID 30636644 2019 Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.

PMID 21123754 2011 Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.

PMID 31473137 2019 Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.

PMID 31055733 2019 Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension.

PMID 23419831 2014 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.

rs429358 in APOE gene and Apolipoproteins E measurement (procedure) PMID 28240269 2017 Connecting genetic risk to disease end points through the human blood plasma proteome.

rs429358 in APOE gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs429358 in APOE gene and C-reactive protein measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 30388399 2018 Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

rs429358 in APOE gene and Cerebral Amyloid Angiopathy PMID 29458411 2018 Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease.

rs429358 in APOE gene and Dementia, Vascular PMID 31473137 2019 Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.

rs429358 in APOE gene and Exudative age-related macular degeneration PMID 26691988 2016 A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

rs429358 in APOE gene and Geographic Atrophy PMID 26691988 2016 A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

rs429358 in APOE gene and High density lipoprotein measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

PMID 25961943 2015 The impact of low-frequency and rare variants on lipid levels.

rs429358 in APOE gene and Hyperopia PMID 30098192 2018 Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect.

rs429358 in APOE gene and Hypertensive disease PMID 31055733 2019 Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension.

rs429358 in APOE gene and Lewy Body Disease PMID 31065058 2019 GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study.

PMID 25188341 2014 Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.

PMID 29263008 2018 Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

rs429358 in APOE gene and Longevity PMID 31413261 2019 A meta-analysis of genome-wide association studies identifies multiple longevity genes.

rs429358 in APOE gene and Low density lipoprotein cholesterol measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs429358 in APOE gene and Memory performance PMID 29274321 2018 Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.

rs429358 in APOE gene and Mental deterioration PMID 28078323 2017 Genetic architecture of age-related cognitive decline in African Americans.

rs429358 in APOE gene and Parkinson Disease PMID 30957308 2019 Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.

rs429358 in APOE gene and Physical Activity Measurement PMID 29899525 2018 Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE.

rs429358 in APOE gene and Platelet Count measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs429358 in APOE gene and RDW - Red blood cell distribution width result PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs429358 in APOE gene and Red cell distribution width determination PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs429358 in APOE gene and Serum total cholesterol measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs429358 in APOE gene and Triglycerides measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

rs429358 in APOE gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs429358 in APOE gene and exudative macular degeneration PMID 26691988 2016 A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.