Gene: IL13

Alternate names for this Gene: IL-13|P600

Gene Summary: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.1

Description of this Gene: interleukin 13

Type of Gene: protein-coding

Gene: TH2LCRR

Alternate names for this Gene: TH2-LCR

Gene Summary:

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.1

Description of this Gene: T helper type 2 locus control region associated RNA

Type of Gene: ncRNA

rs20541 in IL13;TH2LCRR gene and Allergic Reaction PMID 23817569 2013 A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

PMID 29083406 2017 Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.

rs848 in IL13;TH2LCRR gene and Alopecia Areata PMID 25608926 2015 Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.

rs20541 in IL13;TH2LCRR gene and Asthma PMID 29273806 2018 Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

rs20541 in IL13;TH2LCRR gene and Dermatitis, Atopic PMID 23886662 2013 A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.

rs20541 in IL13;TH2LCRR gene and Hodgkin Disease PMID 22286212 2012 Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.

PMID 24920014 2014 A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.

rs20541 in IL13;TH2LCRR gene and Multiple Sclerosis PMID 22190364 2011 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

rs20541 in IL13;TH2LCRR gene and Psoriasis PMID 25903422 2015 Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.

PMID 26626624 2015 Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.

PMID 19169254 2009 Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

PMID 20953187 2010 Association analyses identify six new psoriasis susceptibility loci in the Chinese population.