Gene: PEX14

Alternate names for this Gene: NAPP2|PBD13A|Pex14p|dJ734G22.2

Gene Summary: This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.22

Description of this Gene: peroxisomal biogenesis factor 14

Type of Gene: protein-coding

rs12045923 in PEX14 gene and Allergic Reaction PMID 29679657 2019 Eleven loci with new reproducible genetic associations with allergic disease risk.

PMID 23817569 2013 A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

rs142020459 in PEX14 gene and Alopecia PMID 28196072 2017 Genetic prediction of male pattern baldness.

rs662064 in PEX14 gene and Asthma PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs10864459 in PEX14 gene and Breast Carcinoma PMID 27117709 2016 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.

PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

PMID 23535733 2013 Genome-wide association studies identify four ER negative-specific breast cancer risk loci.

PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

PMID 25751625 2015 Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.

rs616402 in PEX14 gene and Breast size PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs10864462 in PEX14 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs6687430 in PEX14 gene and Hair Color PMID 30531825 2018 Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.

rs648324 in PEX14 gene and Low density lipoprotein cholesterol measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs616488 in PEX14 gene and Malignant neoplasm of breast PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

PMID 23535733 2013 Genome-wide association studies identify four ER negative-specific breast cancer risk loci.

rs636291 in PEX14 gene and Prostate carcinoma PMID 25217961 2014 A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

rs6687430 in PEX14 gene and Respiratory Tract Diseases PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs648324 in PEX14 gene and Serum total cholesterol measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.