Gene: TLR1

Alternate names for this Gene: CD281|TIL|TIL. LPRS5|rsc786

Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.

Gene is located in Chromosome: 4

Location in Chromosome : 4p14

Description of this Gene: toll like receptor 1

Type of Gene: protein-coding

rs11727978 in TLR1 gene and Allergic Reaction PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 23817569 2013 A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

PMID 29083406 2017 Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.

rs5743618 in TLR1 gene and Allergic rhinitis (disorder) PMID 30013184 2018 Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

rs17616434 in TLR1 gene and Allergic sensitization PMID 23817571 2013 Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.

rs4833095 in TLR1 gene and Asthma PMID 24388013 2014 Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.

PMID 30929738 2019 Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.

PMID 31036433 2019 Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs6815814 in TLR1 gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs5743618 in TLR1 gene and Childhood asthma PMID 30929738 2019 Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.

PMID 31036433 2019 Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.

rs4833103 in TLR1 gene and Diabetes PMID 27670767 2018 Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes.

rs4833103 in TLR1 gene and Diabetes Mellitus PMID 27670767 2018 Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes.

rs5743618 in TLR1 gene and Eczema PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs4833095 in TLR1 gene and Hay fever PMID 24388013 2014 Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.

rs5743616 in TLR1 gene and High density lipoprotein measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs4833103 in TLR1 gene and Hypertensive disease PMID 27670767 2018 Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes.

rs5743618 in TLR1 gene and Respiratory Tract Diseases PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs4543123 in TLR1 gene and Scleroderma, Limited PMID 29293537 2018 Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations.

rs5743616 in TLR1 gene and Serum HDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.