GA‐binding protein (GABP) transcription factor gene, also known as the Nuclear Respiratory Factor 2 (NRF2) gene is associated with the synthesis of GABPB1, a key transcriptional activator of numerous nuclear genes which produce various mitochondrial enzymes. The variants of the GABPB1 gene that code for the beta1 subunit of NRF2 protein have been shown to […]

The PPARGC1A gene is associated with the synthesis of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a), which is associated with mitochondrial biogenesis or the production of new mitochondria within the muscle. Specific alleles of this gene are known to either increase or decrease the levels of PGC-1a. People with the A variant of the gene […]