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The Peroxisome Proliferator- Activated Receptor (PPARA) gene is associated with the synthesis of Peroxisome Proliferator- Activated Receptor Alpha (PPARA), a protein associated with the activation of other genes and also in regulation of fatty acid oxidation during exercise. A lack of energy in the cells activate this gene like during endurance exercises or when fasting. Variants of the gene are shown to be associated with endurance, power, aerobic capacity and cardio fitness (heart rate)

PPARA level is higher in tissues which catabolize fatty acids like skeletal and cardiac muscle and the liver while it is lower in other tissues like the pancreas.

Does your 23andme, Ancestry DNA, FTDNA raw data have PPARA gene variant information?

CHIP VersionPPARA SNPs
23andMe (Use your 23andme raw data to know your PPARA Variant)
v1 23andmePresent
v2 23andmePresent
v3 23andmePresent
v4 23andmePresent
V5 23andme (current chip)Present
AncestryDNA  (Use your ancestry DNA raw data to know your PPARA Variant)
v1 ancestry DNAPresent
V2 ancestry DNA (current chip)Present
Family Tree DNA  (Use your FTDNA raw data to know your PPARA Variant)
OmniExpress microarray chipPresent

Association with Endurance:

In a study conducted on athletes, people with G variant were associated with endurance. A similar study conducted on soccer players showed that people with the G variant were highly represented. People with the G variant were found to have higher amount of slow twitch fibers.

Association with Power:

People with the C variant of the gene had better hand grip strength, thereby, better at power based activities than people with the G variant.

Association with Aerobic capacity:

People with the G variant were associated with higher oxygen consumption, thereby better aerobic capacity when compared with people with the C variant of the gene.

Association with Cardio fitness (Oxygen pulse):

People with the G variant were associated with higher values of oxygen pulse.

Genotype   rs4253778PhenotypeRecommendation
GG[Advantage] More likely to have better endurance [Advantage] More likely to have more slow twitch fibers [Advantage] More likely to have better aerobic capacity [Advantage] More likely to have higher oxygen pulseLikely better endurance Include plenty of endurance based activities like dancing and playing cricket into the fitness routine
GCModerate power and enduranceLikely better endurance Include plenty of endurance based activities like dancing and playing cricket into the fitness routine
CC[Advantage] More likely to have better power   [Advantage] More likely to have more fast twitch fibers [Limitation] More likely to have lower aerobic capacity [Limitation] More likely to have lower oxygen pulseLikely better power Include power based activities like kicking a football and squats into the fitness routine


References
:

  1. http://www.ommegaonline.org/article-details/Role-of-Peroxisome-Proliferator-Activated-Receptor-Alpha-(PPARA)-rs4253778-Polymorphism-in-Endurance-Phenotype/1152
  2. https://www.researchgate.net/publication/226721692_PPARa_gene_variation_and_physical_performance_in_Russian_athletes
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157815/

Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”

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