Reports
Health
Wellness
The MCT1 gene is associated with the synthesis of MCT1, a molecule that transports lactic acid across the muscle cell membrane. Specific alleles of this gene are known to either increase or decrease the risk for fatigue and muscle injury after intense exercises. People with the T variant of the gene are associated with lower transport of lactic acid due to lower levels of MCT1, implying that they could experience earlier fatigue onset on exercising.
| CHIP Version | MCT1 SNPs |
| 23andMe (Use your 23andme raw data to know your MCT1 Variant) | |
| v1 23andme | Present |
| v2 23andme | Present |
| v3 23andme | Present |
| v4 23andme | Present |
| V5 23andme (current chip) | Present |
| AncestryDNA (Use your ancestry DNA raw data to know your MCT1 Variant) | |
| v1 ancestry DNA | Present |
| V2 ancestry DNA (current chip) | Present |
| Family Tree DNA (Use your FTDNA raw data to know your MCT1 Variant) | |
| OmniExpress microarray chip | Present |
A study conducted on sprint/power athletes showed that those with the TT genotype of MCT1 were associated with power athletes when compared to people with the A variant. Conversely, in a study conducted on rowers, the AA genotype was associated with greater frequency among endurance athletes.
People with the AA genotype are at a higher risk of muscle injury while the T variant of the gene may have a protective effect due to lowered transport of lactic acid into muscles for oxidation.
| Genotype | Phenotype | Recommendation |
| TT | [Limitation] Lower lactate threshold, hence early fatigue onset [Advantage] More likely to have lower risk of muscle injury [Advantage] Better sprint running performance | Higher risk of fatigue- Mild to moderate intensity exercises will aid in lowering risk of fatigue Better sprint running performance Lower risk of muscle injury- Strength training results in low lactate accumulation for people with T variant. Increasing the intake of magnesium rich foods in the diet like kidney beans, navy beans and pinto beans lower accumulation of lactic acid. |
| AT | Moderate risk of fatigue | Better at endurance activities, such as long distance running, playing tennis, basketball, dancing and aerobics. Increased risk for muscle injuries- Carrying out mild to moderate intensity exercises will lower risk of injuries. Strength training should be carried out with lower weight and more repetitions |
| AA | [Advantage] Higher lactate threshold, hence later fatigue onset [Limitation] More likely to have higher risk of muscle injury [Advantage] Better endurance running performance | Better at endurance activities, such as long distance running, playing tennis, basketball, dancing and aerobics. Increased risk for muscle injuries- Carrying out mild to moderate intensity exercises will lower risk of injuries. Strength training should be carried out with lower weight and more repetitions |
