While you cannot reverse an MTHFR mutation, you can follow the MTHFR diet to manage your symptoms. The MTHFR diet will help tackle the nutritional deficiencies that come with an MTHFR mutation and reduce the risk of developing complications in the long run.
About Xcode Life's MTHFR And Methylation Report
MTHFR Mutations: Overview
The Methylenetetrahydrofolate reductase (MTHFR) gene produces an enzyme of the same name.
This enzyme is involved in methylation, a metabolic process that converts dietary folate (vitamin B9) into its active form, L-Methylfolate.
The MTHFR mutations don’t cause health problems on their own.
However, it can interfere with specific body processes and impair nutrient absorption.
This is why dietary intervention is essential when you have a variant of the MTHFR gene.
Types Of Mutation
You can have one (heterozygous) or two (homozygous) mutations in the MTHFR gene.
The types of mutation on the MTHFR gene are:
- C677T: A study conducted in 2020 showed that 38% of subjects had this variant.
- A1298C: Limited research exists on this variant.
Genetic mutations are inherited from parents.
You can either have both variants or one from either of your parents.
What Happens If You Have MTHFR Mutation
If you have an MTHFR gene mutation, your body cannot properly metabolize folic acid into its active form, folate.
This can cause a folate deficiency in the body, along with other nutritional deficiencies.
Vitamin deficiency can increase the risk of cardiovascular and nervous system disorders.
Also, the MTHFR gene is involved in methylation and conversion of homocysteine into methionine.
Methionine is required for proper muscle growth and functioning.
Those with an MTHFR mutation have problems in methylation and fail to eliminate toxins from the body.
MTHFR and Methylation Genetic Test
Methylation tests are done to evaluate the functionality of the methylation process in the body.
Methylation tests can measure various biomarkers in the body and detect abnormalities.
DNA methylation and homocysteine testing are some of the various methylation tests available.
The DNA methylation test can screen single nucleotide polymorphisms (SNPs) or genetic changes affecting metabolism, detoxification, hormone balance, etc.
While there’s no specific genetic test to determine if you have the MTHFR mutation, a methylation genetic test can detect abnormalities in biomarkers and a possible mutation in this gene.
MTHFR Diet: What To Eat
- Folate-rich foods: Folate is an essential nutrient that is crucial to maintaining overall health. Leafy greens like spinach and kale, legumes, oranges, asparagus, beans, and fortified bread are all rich in folate.
- Foods rich in vitamin B12: Those with a mutation in their MTHFR gene can also experience a deficiency in several other nutrients, such as vitamins B12 and B6. Vitamin B12 supports normal functioning of the brain and nervous system. It is also required for the breakdown of homocysteine. A deficiency in these nutrients can increase homocysteine levels in the body, increasing the risk of cardiovascular disease. Include foods rich in vitamin B, such as leafy greens, whole grains (rice, quinoa, oats), beans, chickpeas, nuts, and dairy products.
- Foods containing choline and methionine: Choline and methionine are another group of nutrients essential for those with a mutant MTHFR gene. Some sources of choline and methionine are egg yolks, liver, soybeans, cruciferous vegetables, nuts, and seeds.
How To Detox Body From MTHFR Mutation?
People living with a variant MTHFR gene can have difficulty eliminating toxins from the body.
- Avoiding plastics and other harmful chemicals in everyday products is a good idea.
- Avoid scented candles since they can release chemicals that might harm your body.
- Ensure you filter the water before using it, and use houseplants to clean indoor air.
- Since alcohol and smoking can interfere with detox pathways, it's best to avoid/limit consumption
- Consuming a high-fiber diet can help support detoxification.
Is The Mediterranean Diet Helpful For MTHFR Mutation?
The Mediterranean diet is rich in fruits, vegetables, and healthy fights and has numerous health benefits.
It can reduce oxidative stress and inflammation associated with an MTHFR mutation.
Also, it can provide adequate nutrition to those with an MTHFR gene mutation.
While evidence suggests a connection between MTHFR mutations, the Mediterranean diet, and obesity, more research is needed to fully understand the complex interactions between these factors and their impact on weight regulation and metabolic health.
Personalized dietary and lifestyle interventions, as well as genetic counseling, may be beneficial for individuals with an MTHFR mutation who are struggling with obesity or weight management.
MTHFR Diet: What To Avoid
Here are a few foods that you should avoid if you have an MTHFR gene variant:
- Foods that can cause inflammation: Processed foods and snacks, packaged foods high in sugar, and processed foods high in saturated fats can cause inflammation and oxidative stress in the body.
- Foods fortified with folic acid: Since individuals with a mutant MTHFR gene cannot metabolize folic acid, an excessive buildup of folic acid in the body can occur. Avoid foods fortified with folic acid, such as cereals, pasta, and breads.
- Alcohol: It can increase oxidative stress on the body and interfere with folate and vitamin B absorption. It is best to limit alcohol consumption if you have an MTHFR variant gene.
Xcode Life's MTHFR and Methylation Report: 15 Genes - 68 Variants - $50 $30
MTHFR Diet: What Supplements To Take?
Individuals with MTHFR mutation might have difficulty getting the required folate from their diets.
Methylfolate and vitamin B12 supplements can be beneficial for such people.
However, talk to your doctor before starting any supplements.
This ensures that you take the correct dosage of these supplements.
Who Is MTHFR Diet Recommended For?
The MTHFR diet may be recommended for people who live with the MTHFR genetic variants.
Those with a mutation in this gene cannot properly metabolize the amino acid homocysteine.
It can lead to a variety of health conditions ranging from depression to coronary heart disease.
They are recommended the MTHFR diet to offset nutritional deficiencies associated with this genetic condition and to prevent further complications or diseases.
FAQs About MTHFR Diet
Is Caffeine Bad For MTHFR?
Studies suggest that coffee can increase the homocysteine levels in those with the MTHFR C677T mutation.
So, moderating caffeine consumption may help such individuals.
However, the study also reported that folic acid can help counteract the homocysteine-increasing effects of coffee.
Can I Have Eggs With MTHFR?
Egg yolks are some of the best sources of the nutrient choline.
Choline helps metabolize homocysteine, an excessive amino acid in people with the MTHFR mutation.
So, ensure that you include eggs in your MTHFR diet.
What Vitamin Is Best For MTHFR?
The MTHFR genetic mutation can cause a deficiency in the B vitamins.
Hence, vitamins B12 and B6 supplements are best for MTHFR genetic mutation.
Is It Possible To Reverse MTHFR Mutation?
Genetic mutations are inherited from parents when you are born.
While it is impossible to reverse MTHFR mutation, you can still manage and overcome your symptoms by making several dietary changes.
What Medication Should Be Avoided For MTHFR Mutation?
Medications that reduce the absorption of B vitamins, such as antacids, metformin, and oral contraceptive pills.
Medications that increase homocysteine, including nitrous oxide.
Always talk to your healthcare provider before you decide to stop taking any medication.
Summary
The MTHFR gene can undergo mutation, resulting in folate and other nutritional deficiencies in the body.
We recommend following an MTHFR diet to compensate for them and reduce the risk of developing long-term complications.
An MTHFR diet consists of foods high in folate and vitamin B12 since those with the mutation can often have deficiencies for these mutations.
Foods with folic acid and those that can cause inflammation are best avoided.
You can start taking supplements if you have the MTHFR gene mutation.
However, we recommend talking to your healthcare provider before starting any supplements.
