Know Your Genes: SGK1 “Salt Sensitivity 2 Gene”

Table of Contents

The Serum and Glucocorticoid regulated kinase 1 (SGK1) gene is associated with the synthesis of serum and glucocorticoid regulated kinase 1, an enzyme which is associated with stress response. This kinase is also known to be associated with renal sodium retention. Increase in SGK1 is shown to be associated with increased sodium reabsorption and increase in blood pressure.

Our ancestors who lived between 2 million and 10,000 years ago were hunters and consumed less than 1g/day of salt from the animals and fruits and vegetables that they ate. Salt began to be used extensively when its properties associated with food preservation was discovered. Currently, salt intake is as high as 10 mg/day, which is shown to be associated with an increase in blood pressure and risk for cardiovascular disease.

Association with Salt Sensitivity:

In a study, people with the C variant were shown to be associated with higher diastolic blood pressure on high salt intake than people with the T variant.

Does you raw data contain the SGK1 variant?

CHIP Version	SGK1 SNPs
23andMe (Use your 23andme raw data to know your SGK1 Variant)
v1 23andme	Present
v2 23andme	Present
v3 23andme	Present
v4 23andme	Present
V5 23andme (current chip)	Present
AncestryDNA (Use your ancestry DNA raw data to know your SGK1 Variant)
v1 ancestry DNA	Present
V2 ancestry DNA (current chip)	Present
Family Tree DNA (Use your FTDNA raw data to know your SGK1 Variant)
OmniExpress microarray chip	Present

Genotype	Phenotype	Recommendations
CC	[Limitation]Salt Sensitive [Limitation]Greater increase in blood pressure on a high salt intake	People with a high blood pressure should practice mindful consumption of salt in the diet Packaged soups, potato chips, sauce tend to have higher salt content The adequate intake of salt in the diet is 1600mg which is equal to half a teaspoon of salt per day
CT	Intermediate response to salt intake and blood pressure
TT	[Advantage]Normal Salt Sensitivity [Advantage]No significant increase in blood pressure in response to high salt diet	Ensure optimum intake of salt in the diet

References:

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“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”