The Serum and Glucocorticoid regulated kinase 1 (SGK1) gene is associated with the synthesis of serum and glucocorticoid regulated kinase 1, an enzyme which is associated with stress response. This kinase is also known to be associated with renal sodium retention. Increase in SGK1 is shown to be associated with increased sodium reabsorption and increase in blood pressure.
Our ancestors who lived between 2 million and 10,000 years ago were hunters and consumed less than 1g/day of salt from the animals and fruits and vegetables that they ate. Salt began to be used extensively when its properties associated with food preservation was discovered. Currently, salt intake is as high as 10 mg/day, which is shown to be associated with an increase in blood pressure and risk for cardiovascular disease.
Association with Salt Sensitivity:
In a study, people with the C variant were shown to be associated with higher diastolic blood pressure on high salt intake than people with the T variant.
Does you raw data contain the SGK1 variant?
| CHIP Version | SGK1 SNPs |
| 23andMe (Use your 23andme raw data to know your SGK1 Variant) | |
| v1 23andme | Present |
| v2 23andme | Present |
| v3 23andme | Present |
| v4 23andme | Present |
| V5 23andme (current chip) | Present |
| AncestryDNA (Use your ancestry DNA raw data to know your SGK1 Variant) | |
| v1 ancestry DNA | Present |
| V2 ancestry DNA (current chip) | Present |
| Family Tree DNA (Use your FTDNA raw data to know your SGK1 Variant) | |
| OmniExpress microarray chip | Present |
Genotype |
Phenotype |
Recommendations |
| CC |
[Limitation]Salt Sensitive [Limitation]Greater increase in blood pressure on a high salt intake |
|
| CT | Intermediate response to salt intake and blood pressure | |
| TT |
[Advantage]Normal Salt Sensitivity [Advantage]No significant increase in blood pressure in response to high salt diet |
|
References:
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“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”
