Know Your Genes: APOA2 “Weight Gain Gene”

The Apolipoprotein A-II (APOA2) gene is associated with the synthesis of Apolipoprotein 2, the second most common protein found in the high density lipoprotein. This protein is shown to be associated with the impairment of the reverse cholesterol transport and the anti-oxidant ability of the high density lipoprotein. People with the T variant of the gene have higher levels of the protein.

Association with Saturated Fat Intake and Weight Gain Tendency:

In a study conducted on adolescents, people with the C variant were found to be associated with greater body fat percentage, visceral fat and HDL-C levels on a high saturated fat intake.

When people with the C variant are given a choice between a bar of chocolate and guacamole, they are more likely to prefer a bar of chocolate, though there is an equal amount of fat in both. This may be because people with C variant are more likely to prefer foods that are rich in saturated fat.

In another study conducted on nearly 2000 individuals, people with the C variant were found to be significantly associated with a higher intake of high fat dairy and higher BMI.  

 

Does your 23andme, Ancestry DNA, FTDNA raw data have APOA2 gene variant information?

CHIP Version APOA2 SNPs
23andMe (Use your 23andme raw data to know your APOA2 Variant)
v1 23andme Present
v2 23andme Present
v3 23andme Present
v4 23andme Present
V5 23andme (current chip) Present
AncestryDNA  (Use your ancestry DNA raw data to know your APOA2 Variant)
v1 ancestry DNA Present
V2 ancestry DNA (current chip) Present
Family Tree DNA  (Use your FTDNA raw data to know your APOA2 Variant)
OmniExpress microarray chip Present

 

Genotype

Rs5082

Phenotype

Recommendations

CC

[Limitation] More likely to consume higher amount of food rich in saturated fat

[Limitation] More likely to have higher BMI on high saturated fat intake

  • Since your genetic type indicates that you may prefer food rich in saturated fat intake which could increase your tendency to gain weight, consciously lower intake of food rich in saturated fat (below 22g per day)
  • Include sufficient physical activity to lower risk for weight gain
  • Ensure healthy snacking practices
CT Moderate BMI
  • Practice mindful eating and continue to eat food rich in saturated fat in moderation
TT

[Advantage] More likely to consume normal amount of food rich in saturated fat

[Advantage] Less likely to have higher BMI on saturated fat intake

 

References:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874956/
  2. https://www.ncbi.nlm.nih.gov/pubmed/?term=Apolipoprotein+A2+Polymorphism+Interacts+with+Intakes+of+Dairy+Foods+to+Influence+Body+Weight+in+2+U.S.+Populations

Related Links:

  1. https://www.xcode.life/dna-and-nutrition/saturated-fat-consumption-and-the-apoa2-gene

 

[idea]Find out which variation of the gene you carry and more at www.xcode.life[/idea]

“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”

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