The Apolipoprotein A-II (APOA2) gene is associated with the synthesis of Apolipoprotein 2, the second most common protein found in the high density lipoprotein. This protein is shown to be associated with the impairment of the reverse cholesterol transport and the anti-oxidant ability of the high density lipoprotein. People with the T variant of the gene have higher levels of the protein.
Association with Saturated Fat Intake and Weight Gain Tendency:
In a study conducted on adolescents, people with the C variant were found to be associated with greater body fat percentage, visceral fat and HDL-C levels on a high saturated fat intake.
When people with the C variant are given a choice between a bar of chocolate and guacamole, they are more likely to prefer a bar of chocolate, though there is an equal amount of fat in both. This may be because people with C variant are more likely to prefer foods that are rich in saturated fat.
In another study conducted on nearly 2000 individuals, people with the C variant were found to be significantly associated with a higher intake of high fat dairy and higher BMI.
Does your 23andme, Ancestry DNA, FTDNA raw data have APOA2 gene variant information?
| CHIP Version | APOA2 SNPs |
| 23andMe (Use your 23andme raw data to know your APOA2 Variant) | |
| v1 23andme | Present |
| v2 23andme | Present |
| v3 23andme | Present |
| v4 23andme | Present |
| V5 23andme (current chip) | Present |
| AncestryDNA (Use your ancestry DNA raw data to know your APOA2 Variant) | |
| v1 ancestry DNA | Present |
| V2 ancestry DNA (current chip) | Present |
| Family Tree DNA (Use your FTDNA raw data to know your APOA2 Variant) | |
| OmniExpress microarray chip | Present |
GenotypeRs5082 |
Phenotype |
Recommendations |
| CC |
[Limitation] More likely to consume higher amount of food rich in saturated fat [Limitation] More likely to have higher BMI on high saturated fat intake |
|
| CT | Moderate BMI |
|
| TT |
[Advantage] More likely to consume normal amount of food rich in saturated fat [Advantage] Less likely to have higher BMI on saturated fat intake |
References:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874956/
- https://www.ncbi.nlm.nih.gov/pubmed/?term=Apolipoprotein+A2+Polymorphism+Interacts+with+Intakes+of+Dairy+Foods+to+Influence+Body+Weight+in+2+U.S.+Populations
Related Links:
[idea]Find out which variation of the gene you carry and more at www.xcode.life[/idea]
“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”
