The Peroxisome Proliferator- Activated Receptor Delta (PPARD) gene is associated with the synthesis of Peroxisome Proliferator- Activated Receptor Delta (PPARD), a protein associated with cell differentiation and lipid metabolism. Variations of this gene are associated with endurance and HDL cholesterol levels upon exercising.
Association with Endurance:
In a study conducted on athletes, people with the C variant were associated with endurance. In another similar study, people with the C variant were found to be associated with better endurance.
Association with HDL levels upon Exercising:
In a study on PPARD gene polymorphisms and lipid responses upon exercising, people with the C variant showed a greater increase in HDL-C levels. In a study conducted on 2700 study participants, PPARD gene polymorphisms were shown to be associated with changes in HDL levels upon exercising.
Which ancestry raw data file should you use to know your PPARD variant?
| CHIP Version | PPARD SNPs |
| 23andMe (Use your 23andme raw data to know your PPARD Variant) | |
| v1 23andme | Present |
| v2 23andme | Present |
| v3 23andme | Present |
| v4 23andme | Present |
| V5 23andme (current chip) | Present |
| AncestryDNA (Use your ancestry DNA raw data to know your PPARD Variant) | |
| v1 ancestry DNA | Present |
| V2 ancestry DNA (current chip) | Present |
| Family Tree DNA (Use your FTDNA raw data to know your PPARD Variant) | |
| OmniExpress microarray chip | Present |
Genotype |
Phenotype |
Recommendation |
| CC |
[Advantage] More likely to have better endurance [Advantage] More likely to have higher HDL levels upon exercising |
|
| CT |
Moderate endurance |
|
| TT |
[Limitation] More likely to have lower endurance [Limitation] More likely to have lower HDL levels upon exercising |
|
References:
- https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor_delta
- https://www.ncbi.nlm.nih.gov/pubmed/19383774
- https://www.ncbi.nlm.nih.gov/pubmed/26231489
- https://www.ncbi.nlm.nih.gov/pubmed/17259439
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“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”
