The 23andMe MTHFR gene test is one of the most sought-after, requested by many 23andMe customers.
23andMe tests for thousands of single nucleotide polymorphisms and this includes the well known MTHFR gene mutations.
23andMe provides your genomic information in the form of raw data that can be easily accessed and then uploaded onto sites like Xcode Life to find out the specific variant carried.
|AA||2 copies of the variant allele, reduction in MTHFR enzyme activity by nearly 80%|
|AG||1 copy of the variant allele, reduction in MTHFR enzyme activity by 40%|
|GG||Both normal alleles, no reduction in enzyme activity due to this polymorphism|
|GG||2 copies of the variant allele, reduction in MTHFR enzyme activity|
|GT||1 copy of the variant allele, reduction in MTHFR enzyme activity|
|TT||Both normal alleles, no reduction in enzyme activity due to this polymorphism|
Apart from 23andMe, raw data from companies like AncestryDNA.com, FTDNA.com, and other similar genetic testing service providers may be uploaded to find out more about your MTHFR gene mutations.
Let us find out more about this gene mutation and how it is associated with your health.
The methylenetetrahydrofolate reductase (MTHFR) gene carries instructions for the synthesis of an enzyme with the same name.
This important enzyme is associated with the processing of amino acids, which are the building blocks for protein molecules.
In the MTHFR pathway, the enzyme converts 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate.
This is one of the steps in the process that converts the ‘ harmful’ amino acid homocysteine to the ‘useful’ amino acid, methionine.
Learn about all the genes covered in the MTHFR raw data analysis report
The MTHFR test has become increasingly popular because of all the awareness currently being generated by widespread DNA testing.
The test is used to identify mutations in two specific regions of the MTHFR gene- C677T and A1298C that are associated with the level of activity of the MTHFR enzyme and the corresponding ability to utilize folate.
The 23andMe MTHFR test will help in identifying the level of MTHFR enzyme activity, which in turn corresponds to how well homocysteine is metabolized and converted into methionine.
This is necessary for the synthesis of DNA, serotonin and melatonin.
Vitamin B9 (Folate) is vital as it is necessary in the production of all cells.
It is required for DNA synthesis, tissue growth during pregnancy, cell division, immune system, blood formation and other important physiological functions.
23andMe MTHFR mutation prevalence in the U.S,
MTHFR C677T mutation is the most common and is found at a higher frequency in certain ethnic populations.
23andMe MTHFR mutation prevalence in North America, Australia and Europe
|Contents||MTHFR status from 23andme raw data||MTHFR status from Ancestry DNA raw data|
|Raw data||23andme raw data can be downloaded||Ancestry DNA raw data can be downloaded|
|MTHFR C677T and A1298C||23andme MTHFR test includes these two SNPs||AncestryDNA MTHFR test includes these two SNPs|
|MTHFR test cost||23andme test cost is $99||Ancestry DNA test cost is $99 (with a 10% discount on offer currently)|
|MTHFR test report||23andme report does not include information on MTHFR gene. Information is present as raw data which needs interpretation.||Ancestry report does not include information on MTHFR gene. Information is present as raw data which needs interpretation.|
|MTHFR gene report from Alternate providers||A variance report generated using 23andme raw data V5 chip has less number of SNPs compared to ancestry DNA.||A variance report generated using Ancestry DNA raw data has more number of SNPs compared to 23andme V5 chip.|
Here are a few studies which show an association with various health conditions among people with the variant alleles.
The MTHFR 23andme results can be used to interpret the level of enzyme activity, which in turn can be used to identify the extent of folate supplementation required.
Though it has been shown that reduced MTHFR enzyme function is associated with elevated homocysteine levels, many people have normal homocysteine levels, especially in places like the United States where there is a fortification of food with folic acid.
According to the NIH, there are over 40 mutations in the MTHFR gene that are associated with poor enzyme activity and associated increase in homocysteine levels in the body.
Certain genetic testing companies check for only the two major MTHFR gene mutations, while there are many others, like us, who give you a detailed report based on the 23andme MTHFR variants present in the 23andme raw data.
The Xcode Life MTHFR report covers several of these genetic variations covered in the NIH publication above.