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How To Interpret Your MTHFR Results From DNA Raw Data

Last updated: March 6, 2024

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10 comments on “How To Interpret Your MTHFR Results From DNA Raw Data”

    1. Hi Katy, thanks for getting in touch with us. In the 677th position in the MTHFR gene, people either have the C allele (more common) or the T allele – so the possible genotypes are CC, CT, and TT. A is complementary to T on the opposite strand of the DNA. Hope this clarifies!

  1. Hello,

    I’m confused with my results. I’ve got

    RS1801133 GG ( normal enzyme activity)
    RS1801131 GG. ( reduced enzyme activity)

    Moderately likely moderate lower MTHFR Enzyme activity.

    Does this make me Heterozygous or Homozygous?

    Thanks in advance.

    1. Hello Ben! In rs1801133, you are homozygous for the major allele (C or G), which implies a likelihood of normal MTHFR enzyme activity. In rs1801131, you are homozygous for the variant allele (C or G). which implies a likelihood of reduced MTHFR enzyme activity. Overall, this translates to a likelihood of moderately reduced enzyme activity.

  2. Severely decreased activity 677TT, 1298AA. Has anyone sought treatment or supplementation for MTHFR? How did it go? Having trouble finding a doctor that has knowledge and have been self treating with methylfolate.

  3. Thanks so touch for this article. I had recent blood work done and noticed a reduced RBC folate and elevated homocysteine. Armed with this information I found your article and looked into the raw data from my 23andMe test I’d had done this spring. Lo and behold, I see I have the MTHFR A1298C mutation GT (one copy of the variant allele). Now, I can consider supplementation to counter this.

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