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How To Interpret Your MTHFR Results From DNA Raw Data

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Last updated: May 21, 2025

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Karpowicz Pawel
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May 31, 2021
Simply the best DNA service
I am very pleased with Xcode professional service. My comprehensive reports was generated fast. I could find out a lot about my health, allergy, fitness, nutrition and skin info I never knew before from my raw DNA data. Xcode has the best deal prices on the internet. Highly recommended you won't regret.
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May 30, 2021
Finding out random genetic variations
Finding out random genetic variations you might be predisposed to. It gives out likely or unlikely expressions you might have. I got the health, fitness and nutritional pack and I saw confirmations of experiences that I've uncovered about myself, like having unordinary grip strength. It's neat to have this kind of validation and proof! I plan to reference my xcode pdfs since there's a lot to digest! I find the vitamins my body would likely prefer to be my favorite part of it. I want something more definitive to understand myself, like not what's "likely", but genes are complicated and xcode just provides what's likely and that's ok. What I would prefer is probably a whole other complex science. It was worth it.
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April 3, 2023
I am so glad I found XCode - BRCA and MTHFR
I am so glad I found XCode! I had my DNA results from Ancestry and was able to upload them to XCode and get answers to so many of my gene questions. Super quick turn around - they usually quote 24 hours turn around but for me it was more like 12 hours. I recently had a friend diagnosed with triple negative breast cancer so I felt I needed to get answers to my breast cancer possibilities. XCode gave me answers in ~12 hours. THANK YOU!
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December 4, 2021
Xcode is great for those who are curious about their genes
X code is great for those who are curious about their genes and how to navigate a healthier lifestyle according to it. Some of the reports are quite straightforward and easy to understand while others are a bit more complex and require some studying. Nevertheless, dedicating time to understanding how I could treat my body properly genetically speaking has been a great turning point in my life. Highly recommended.
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May 10, 2021
Accuracy is spot-on
I have used Xcode for multiple reports and I would highly recommend the service for all friends and family. The accuracy is spot on, the cost is affordable and reports are delivered back very quickly. I was able to use my MTHFR report I did years ago for proper detox methods, and my most recent, covid reports, which I did for all my family members, to add awareness of how it might affect me.
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10 comments on “How To Interpret Your MTHFR Results From DNA Raw Data”

    1. Hi Katy, thanks for getting in touch with us. In the 677th position in the MTHFR gene, people either have the C allele (more common) or the T allele - so the possible genotypes are CC, CT, and TT. A is complementary to T on the opposite strand of the DNA. Hope this clarifies!

  1. Hello,

    I’m confused with my results. I’ve got

    RS1801133 GG ( normal enzyme activity)
    RS1801131 GG. ( reduced enzyme activity)

    Moderately likely moderate lower MTHFR Enzyme activity.

    Does this make me Heterozygous or Homozygous?

    Thanks in advance.

    1. Hello Ben! In rs1801133, you are homozygous for the major allele (C or G), which implies a likelihood of normal MTHFR enzyme activity. In rs1801131, you are homozygous for the variant allele (C or G). which implies a likelihood of reduced MTHFR enzyme activity. Overall, this translates to a likelihood of moderately reduced enzyme activity.

  2. Severely decreased activity 677TT, 1298AA. Has anyone sought treatment or supplementation for MTHFR? How did it go? Having trouble finding a doctor that has knowledge and have been self treating with methylfolate.

  3. Thanks so touch for this article. I had recent blood work done and noticed a reduced RBC folate and elevated homocysteine. Armed with this information I found your article and looked into the raw data from my 23andMe test I'd had done this spring. Lo and behold, I see I have the MTHFR A1298C mutation GT (one copy of the variant allele). Now, I can consider supplementation to counter this.

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