Know Your Genes: TFAP2B “Protein Gene”

The Transcription factor AP 2 beta (TFAP2B) gene is associated with the synthesis of transcription factor AP 2 beta, which is associated with the stimulation of cell proliferation and in the destruction of cells (apoptosis).

Our ancestors consumed a diet that is believed to have been 35% high in fats, 35% from carbohydrates and 30% from proteins. People with certain variations of the TFAP2B are associated with a better response to high protein in the diet.

Association of Protein Intake and Weight Gain Tendency:

In a study conducted to identify a suitable diet for weight loss, a trial was conducted among 932 obese families. People with the A variant of the gene were shown to be associated with lower weight regain on a high protein diet (>5.4 points higher protein intake than the normal protein intake group) and low G.I carbohydrates group.

In another study, people with the G variant on a high protein diet gained 1.84 kg per risk allele, when compared to people with the AA genotype.

 

Does your 23andme, Ancestry DNA, FTDNA raw data have your TFAP2B variants?

CHIP Version TFAP2B SNPs
23andMe (Use your 23andme raw data to know your TFAP2B Variant)
v1 23andme Present
v2 23andme Present
v3 23andme Present
v4 23andme Present
V5 23andme (current chip) Present
AncestryDNA  (Use your ancestry DNA raw data to know your TFAP2B Variant)
v1 ancestry DNA Present
V2 ancestry DNA (current chip) Present
Family Tree DNA  (Use your FTDNA raw data to know your TFAP2B Variant)
OmniExpress microarray chip Present

 

Genotype

rs987237

Phenotype

Recommendations

GG [Limitation] More likely to have higher weight regain on a high protein diet
  • Eat a balanced meal
AG Moderate weight regain on a high protein diet
AA [Advantage] More likely to have lower weight regain on a high protein diet
  • A high protein diet helps curb hunger
  • Protein rich food sources are seafood, cheese, soy, eggs, beans, nuts, seeds and meat
  • Choose protein sources that have nutritive value like salmon which is rich in omega 3 or beans which is rich in fibre.

References:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424378/
  2. https://en.wikipedia.org/wiki/TFAP2B
  3. https://ghr.nlm.nih.gov/gene/TFAP2B#conditions

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“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”

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