The Transcription factor AP 2 beta (TFAP2B) gene is associated with the synthesis of transcription factor AP 2 beta, which is associated with the stimulation of cell proliferation and in the destruction of cells (apoptosis).
Our ancestors consumed a diet that is believed to have been 35% high in fats, 35% from carbohydrates and 30% from proteins. People with certain variations of the TFAP2B are associated with a better response to high protein in the diet.
Association of Protein Intake and Weight Gain Tendency:
In a study conducted to identify a suitable diet for weight loss, a trial was conducted among 932 obese families. People with the A variant of the gene were shown to be associated with lower weight regain on a high protein diet (>5.4 points higher protein intake than the normal protein intake group) and low G.I carbohydrates group.
In another study, people with the G variant on a high protein diet gained 1.84 kg per risk allele, when compared to people with the AA genotype.
Does your 23andme, Ancestry DNA, FTDNA raw data have your TFAP2B variants?
|CHIP Version||TFAP2B SNPs|
|23andMe (Use your 23andme raw data to know your TFAP2B Variant)|
|V5 23andme (current chip)||Present|
|AncestryDNA (Use your ancestry DNA raw data to know your TFAP2B Variant)|
|v1 ancestry DNA||Present|
|V2 ancestry DNA (current chip)||Present|
|Family Tree DNA (Use your FTDNA raw data to know your TFAP2B Variant)|
|OmniExpress microarray chip||Present|
|GG||[Limitation] More likely to have higher weight regain on a high protein diet||
|AG||Moderate weight regain on a high protein diet|
|AA||[Advantage] More likely to have lower weight regain on a high protein diet||
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“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”