The Transcription factor AP 2 beta (TFAP2B) gene is associated with the synthesis of transcription factor AP 2 beta, which is associated with the stimulation of cell proliferation and in the destruction of cells (apoptosis).
Our ancestors consumed a diet that is believed to have been 35% high in fats, 35% from carbohydrates and 30% from proteins.
People with certain variations of the TFAP2B are associated with a better response to high protein in the diet.
Association of Protein Intake with Weight Gain Tendency
People with the A variant of the gene were shown to be associated with lower weight regain on a high protein diet (>5.4 points higher protein intake than the normal protein intake group) and low G.I carbohydrates group.
In another study, people with the G variant on a high protein diet gained 1.84 kg per risk allele, when compared to people with the AA genotype.
Does your 23andme, Ancestry DNA, FTDNA raw data have your TFAP2B variants?
|CHIP Version||TFAP2B SNPs|
|23andMe (Use your 23andMe raw data to know your TFAP2B Variant)|
|v5 23andMe (current)||Present|
|AncestryDNA (Use your ancestry DNA raw data to know your TFAP2B Variant)|
|v2 AncestryDNA (current)||Present|
|Family Tree DNA (Use your FTDNA raw data to know your TFAP2B Variant)|
|OmniExpress microarray chip||Present|
TFAP2B variants and its implications - Protein intake
|GG||[Limitation] More likely to have higher weight regain on a high protein diet||Eat a balanced meal|
|AG||Moderate weight regain on a high protein diet||Eat a balanced meal|
|AA||[Advantage] More likely to have lower weight regain on a high protein diet||A high protein diet helps curb hunger|
Protein rich food sources are seafood, cheese, soy, eggs, beans, nuts, seeds and meat
Choose protein sources that have nutritive value like salmon which is rich in omega 3 or beans which is rich in fiber.
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