DNA Raw Data Analysis For Alcohol Flush: A Healthy Glow Or A Health Concern?

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What is alcohol flush?

The consumption of alcohol in some individuals causes blotches of erythema on their face and neck region and in sometimes on the entire body. Such an event is called an alcohol flush reaction.

This occurs in people who are unable to digest alcohol properly.

Accumulation of acetaldehyde in the body after alcohol consumption leads to this reaction.


What causes alcohol flush reaction?

When you consume alcohol, it gets metabolized to its byproduct acetaldehyde.

In typical cases, acetaldehyde gets metabolized further.

However, some individuals have a defective gene that prevents the further metabolism of acetaldehyde. This causes its accumulation in the body resulting in alcohol flush reaction.


What is low alcohol tolerance?

Alcohol tolerance is defined as your body’s response to the functional effects of alcohol.

This includes the speed of recovery from inebriation, direct tolerance of alcohol, or the resistance to develop alcoholism.

Someone who is unable to tolerate alcohol or lacks the high tolerance levels is said to have low alcohol tolerance or is said to be alcohol intolerant.


Is there a test for alcohol intolerance?

One of the first things your doctor does when you report with suspected alcohol flush reaction is to perform a physical examination. After this, two other tests are performed:


Skin Test

It is performed to detect if you are allergic to a substance in an alcoholic beverage such as grains.

A little amount of the substance is injected into your skin, and if the skin appears red and raised, you are tested positive for the allergy.

Blood Test

A blood test is done to detect the presence of antibodies like IgE that are found in the blood when there is a reaction to the allergic substance in alcohol.

Genetic Test

The gene responsible for acetaldehyde metabolism in the body is ALDH2 that produces the enzyme ALDH2 or Aldehyde Dehydrogenase 2.

Individuals who suffer from an alcohol flush reaction have a faulty or deficient ALDH2 gene, and this can be detected using genetic testing.


What enzyme breaks down alcohol?

Enzyme alcohol dehydrogenase is responsible for breaking down alcohol to aldehyde (acetaldehyde).

What is acetaldehyde dehydrogenase?

Aldehyde dehydrogenases are a group of enzymes that are responsible for the metabolism of aldehydes.

Acetaldehyde dehydrogenase is one such enzyme that is responsible for the catabolism of acetaldehyde.

It is a polymorphic enzyme and oxidizes acetaldehyde to acetate (carboxylic acid). Acetate is then flushed out of the body.

ALDH1 and ALDH2 are two types of aldehyde dehydrogenases.


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ALDH2 deficiency

ALDH2 is an enzyme coded by the ALDH2 gene.

So, a deficiency of ALDH2 means a deficiency in the enzyme that hampers the breakdown of alcohol in the liver, thereby hindering the elimination of toxins.


How can you stop an alcohol flush reaction?

There is no definitive treatment for alcohol flush reaction.

However, there are ways of managing or reducing its intensity:

  1. Reduce the intake of dark-colored alcoholic drinks and stick to light colored ones.
  2. Use antihistamines.


Is alcohol flush harmful to your health?

People who suffer from alcohol flush reaction are at a higher risk of developing esophageal cancer.


How long does an alcohol flush reaction last?

There is no set time frame as to when the symptoms of the reaction will subside.

After the reaction sets in, it usually settles down after a few hours.


How do I know if I have alcohol intolerance?

Minor reactions to alcohol consumption are common.

If you experience the following symptoms, you are most likely alcohol intolerant:

  1. Erythema (facial reddening)
  2. Allergic reactions/rash/hives
  3. Runny/stuffy nose
  4. Nausea
  5. Vomiting
  6. Diarrhea


Alcohol flush reactions

Why do I bleed after a night of drinking?

Alcohol irritates the gastric lining.

When you drink alcohol, even a small quantity of it, causes your stomach to produce acid.

When excess alcohol is consumed, it leads to increased production of stomach acid, which can lead to gastritis.

In many cases, due to excess alcohol, it triggers pain in the stomach, causes diarrhea, vomiting and even bleeding.


Why do my ears burn when I drink alcohol?

Alcohol affects almost all parts of our body.

When excess alcohol is consumed, it affects the part of the brain that controls hearing.

In fact, alcohol consumption affects ears and hearing in more than one way.

When we drink alcohol, it also gets absorbed in the fluid of our ears and causes a burning sensation.


Does drinking alcohol cause red face?

Yes, drinking alcohol can cause erythema or red blotches on the face, neck, shoulder and other areas of the body.


Does alcohol cause hot flashes?

Alcohol causes hot flashes in women, especially those going through menopause.


What causes my face to flush?

Flushed skin occurs when thousands of tiny blood vessels under the skin dilate, and there is an increase in blood flow through them.

This causes them to appear red or pink based on skin color.


Is alcohol flush reaction an allergy?

Alcohol flush reaction is different from the allergic reaction to sulfites or other components in alcohols and can cause reddening of the skin on the face and other parts of the body.


Does alcohol increase body temperature?

Having even a few sips of alcohol makes you feel warmer.

This is because alcohol makes the blood vessels underneath your skin dilate and increases the blood flow in them which makes you feel warm.

But in reality, alcohol reduces your core temperature.


What are some steps to reduce alcohol consumption?

Reducing alcohol consumption can immensely improve your health. Here is a list of few things you can do to help you reduce drinking:

  1. Set realistic goals
  2. Count the number of drinks you consume
  3. Measure your drinks
  4. Drink slowly
  5. Space out your drinks along with lots of food
  6. Avoid triggers like drinking with family or friends
  7. Learn to say ‘no.’


What percentage of alcohol does the liver break down?

Once you consume alcohol, it goes directly down the esophagus, to the stomach and the small intestine.

Once it reaches the stomach, about 20% of it moves into small blood vessels that carry water and nutrients throughout the body.

The remaining 80% reaches the small intestine and enters other groups of blood vessels that travel throughout the body.


Can you take Pepcid with alcohol?

No, you should not consume alcohol with Pepcid as it increases the damage to your stomach lining.


Can you drink alcohol while taking Zantac?

Just like Pepcid, one should avoid alcohol consumption while taking Zantac as it can increase the damage to the stomach lining.


Can you drink alcohol with antihistamines?

It is best to avoid taking alcohol with antihistamines as older types of drug can lead to drowsiness.


Can Asians consume alcohol?

Yes, Asians can drink alcohol.

But, one in three East Asians has an inherited deficiency in one of the enzymes that break down alcohol.

This results in the Alcohol Flush reaction.


Why do Asians get red when they drink?

A defect in the aldehyde dehydrogenase enzyme that is responsible for the degradation of alcohol is seen in East Asians.

Every 1 in 3 East Asian has this defective gene that leads to the accumulation of acetaldehyde that leads to alcohol flush reaction.



Can alcohol cause hives?

Alcohols like wines can cause hives in people who are already prone to developing them.

This is because wine contains antihistaminic compounds which cause flushing, redness of face and neck, and hives.


Can you drink alcohol when you have hives?

It is strictly advised not to consume alcohol when you have hives.

Firstly, it can aggravate the condition.

Secondly, it may interfere or interact with your medications.

Lastly, if you are on antihistamines, alcohol can cause drowsiness.


Can alcohol cause miscarriage?

Studies report that drinking alcohol can increase the risk of miscarriage in women during the first four months of pregnancy by 1.5 times, compared to the women who don’t consume any alcohol during pregnancy

In fact, doctors across the world recommend not to drink throughout the pregnancy to avoid chances of miscarriage and congenital disabilities in the fetus.


How does alcohol affect the kidneys?

Kidneys perform essential functions in the body, one of which is filtering blood to remove toxins and other harmful substances which are later eliminated from the body.

Alcohol causes a change in the functioning of the kidneys and reduces their ability to filter your blood.

Excess alcohol consumption leads to an increase in blood pressure and dehydration of body cells.

Both of these can affect your kidneys.


Does consuming too much alcohol cause urinary tract infection?

Chronic alcoholism has a severe impact on the health of organs including the kidneys.

Continued or excessive consumption of alcohol contributes to high blood pressure and damages the cells of the kidney.

This can result in blood or proteins in the urine.


What is alcoholic intoxication?

Alcoholic intoxication is the excessive drunkenness or alcohol poisoning that occurs immediately after the consumption of ethanol.

Poor coordination and mild sedation are symptoms of low dose alcoholic intoxication.

At high doses, the symptoms are more pronounced and can include slurring of speech, loss of memory, difficulty in walking, and vomiting.

Alcoholic intoxication often occurs after 2-3 drinks, and people with poor tolerance to alcohol are at a higher risk of developing it.


What is a yeast allergy?

Yeast is a fungus that is commonly used in cooking, baking and preparation of alcoholic beverages like beer.

Individuals who are allergic to the fungus suffer from a hypersensitivity reaction on exposure to or consumption of foods containing the fungus.

Mild symptoms include gastrointestinal troubles like diarrhea, vomiting, nausea and a skin rash or similar reaction.

In rare cases, people develop a severe anaphylactic reaction to yeast.


Does alcohol increase your appetite?

According to a few studies, alcohol is said to stimulate and increase your appetite.

It is said to also increase energy intake in people who have a poor appetite.

However, this has not been proven, and alcohol’s effect on appetite remains a grey area.


How does alcohol affect blood pressure and heart rate?

Drinking alcohol in excess amounts and for a continuous period leads to a definite increase in blood pressure and heart rate.

At times, blood pressure can increase to very unhealthy levels, which can be fatal.

Alcohol also contains lots of calories, which along with increased blood pressure are high-risk factors for developing cardiovascular diseases.


Can alcohol cause hearing problems?

Alcohol consumption can cause many problems in the ear.

Excessive alcohol consumption over a long period can damage the central auditory cortex of the brain that can result in shrinkage of the brain.

Other problems that alcohol can cause to the ears include:

  • Hear impairment despite proper functioning of ears due to the damage to the auditory part of the brain
  • Temporary or permanent hearing loss.


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